| Full name: mitochondrial ribosomal protein S28 | Alias Symbol: MRP-S28|HSPC007|MRPS35 | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 28957 | HGNC ID: HGNC:14513 | Ensembl Gene: ENSG00000147586 | OMIM ID: 611990 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPS28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS28 | 28957 | 219819_s_at | 0.6090 | 0.1478 | |
| GSE20347 | MRPS28 | 28957 | 219819_s_at | 0.7625 | 0.0008 | |
| GSE23400 | MRPS28 | 28957 | 219819_s_at | 0.7605 | 0.0000 | |
| GSE26886 | MRPS28 | 28957 | 219819_s_at | 0.6813 | 0.0178 | |
| GSE29001 | MRPS28 | 28957 | 219819_s_at | 0.6961 | 0.0389 | |
| GSE38129 | MRPS28 | 28957 | 219819_s_at | 0.8434 | 0.0000 | |
| GSE45670 | MRPS28 | 28957 | 219819_s_at | 0.6020 | 0.0009 | |
| GSE63941 | MRPS28 | 28957 | 219819_s_at | 0.8852 | 0.1282 | |
| GSE77861 | MRPS28 | 28957 | 219819_s_at | 0.3282 | 0.2481 | |
| GSE97050 | MRPS28 | 28957 | A_23_P169050 | 0.4380 | 0.1754 | |
| SRP007169 | MRPS28 | 28957 | RNAseq | 0.1537 | 0.6827 | |
| SRP008496 | MRPS28 | 28957 | RNAseq | 0.1473 | 0.5665 | |
| SRP064894 | MRPS28 | 28957 | RNAseq | 0.8909 | 0.0001 | |
| SRP133303 | MRPS28 | 28957 | RNAseq | 0.3988 | 0.0408 | |
| SRP159526 | MRPS28 | 28957 | RNAseq | 0.0610 | 0.8422 | |
| SRP193095 | MRPS28 | 28957 | RNAseq | -0.0667 | 0.6685 | |
| SRP219564 | MRPS28 | 28957 | RNAseq | 0.5642 | 0.0498 | |
| TCGA | MRPS28 | 28957 | RNAseq | 0.2343 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPS28 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRPS28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS28 | 28957 | 16 | 1 | 13 | |
| GSE20123 | MRPS28 | 28957 | 18 | 1 | 11 | |
| GSE43470 | MRPS28 | 28957 | 18 | 1 | 24 | |
| GSE46452 | MRPS28 | 28957 | 21 | 0 | 38 | |
| GSE47630 | MRPS28 | 28957 | 23 | 0 | 17 | |
| GSE54993 | MRPS28 | 28957 | 0 | 19 | 51 | |
| GSE54994 | MRPS28 | 28957 | 30 | 0 | 23 | |
| GSE60625 | MRPS28 | 28957 | 0 | 4 | 7 | |
| GSE74703 | MRPS28 | 28957 | 15 | 1 | 20 | |
| GSE74704 | MRPS28 | 28957 | 12 | 0 | 8 | |
| TCGA | MRPS28 | 28957 | 50 | 3 | 43 |
Total number of gains: 203; Total number of losses: 30; Total Number of normals: 255.
Somatic mutations of MRPS28:
Generating mutation plots.
Highly correlated genes for MRPS28:
Showing top 20/1492 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS28 | TOP1MT | 0.801543 | 4 | 0 | 4 |
| MRPS28 | TP53RK | 0.783077 | 3 | 0 | 3 |
| MRPS28 | TMEM138 | 0.768509 | 3 | 0 | 3 |
| MRPS28 | ATP6V1C1 | 0.767952 | 9 | 0 | 8 |
| MRPS28 | TMEM70 | 0.760009 | 8 | 0 | 8 |
| MRPS28 | NUDCD1 | 0.759449 | 5 | 0 | 4 |
| MRPS28 | ENY2 | 0.754153 | 10 | 0 | 10 |
| MRPS28 | RPF2 | 0.748076 | 4 | 0 | 4 |
| MRPS28 | PUF60 | 0.741396 | 9 | 0 | 8 |
| MRPS28 | RNF149 | 0.734493 | 3 | 0 | 3 |
| MRPS28 | MRPL13 | 0.733063 | 11 | 0 | 8 |
| MRPS28 | ZNF680 | 0.733056 | 3 | 0 | 3 |
| MRPS28 | COPS5 | 0.73188 | 10 | 0 | 10 |
| MRPS28 | OTUD6B | 0.730537 | 4 | 0 | 4 |
| MRPS28 | PDIA6 | 0.730443 | 8 | 0 | 7 |
| MRPS28 | ARL13B | 0.729391 | 3 | 0 | 3 |
| MRPS28 | TATDN1 | 0.721797 | 6 | 0 | 5 |
| MRPS28 | NUS1 | 0.721719 | 4 | 0 | 4 |
| MRPS28 | TRUB2 | 0.72166 | 3 | 0 | 3 |
| MRPS28 | BLCAP | 0.719951 | 4 | 0 | 4 |
For details and further investigation, click here
