| Full name: DEAH-box helicase 36 | Alias Symbol: MLEL1|KIAA1488|RHAU | ||
| Type: protein-coding gene | Cytoband: 3q25.2 | ||
| Entrez ID: 170506 | HGNC ID: HGNC:14410 | Ensembl Gene: ENSG00000174953 | OMIM ID: 612767 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DHX36:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHX36 | 170506 | 223139_s_at | 0.4920 | 0.3653 | |
| GSE26886 | DHX36 | 170506 | 223139_s_at | 0.9159 | 0.0001 | |
| GSE45670 | DHX36 | 170506 | 223139_s_at | 0.5661 | 0.0047 | |
| GSE53622 | DHX36 | 170506 | 59927 | 0.8471 | 0.0000 | |
| GSE53624 | DHX36 | 170506 | 59927 | 0.9263 | 0.0000 | |
| GSE63941 | DHX36 | 170506 | 223139_s_at | 1.2358 | 0.0103 | |
| GSE77861 | DHX36 | 170506 | 223139_s_at | 1.5309 | 0.0075 | |
| GSE97050 | DHX36 | 170506 | A_23_P57697 | 0.5687 | 0.1020 | |
| SRP007169 | DHX36 | 170506 | RNAseq | 2.3401 | 0.0000 | |
| SRP008496 | DHX36 | 170506 | RNAseq | 2.1999 | 0.0000 | |
| SRP064894 | DHX36 | 170506 | RNAseq | 0.5845 | 0.0126 | |
| SRP133303 | DHX36 | 170506 | RNAseq | 0.9293 | 0.0000 | |
| SRP159526 | DHX36 | 170506 | RNAseq | 1.0714 | 0.0000 | |
| SRP193095 | DHX36 | 170506 | RNAseq | 0.7580 | 0.0000 | |
| SRP219564 | DHX36 | 170506 | RNAseq | 0.4330 | 0.2439 | |
| TCGA | DHX36 | 170506 | RNAseq | 0.1819 | 0.0004 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by DHX36 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHX36:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHX36 | 170506 | 21 | 1 | 8 | |
| GSE20123 | DHX36 | 170506 | 21 | 1 | 8 | |
| GSE43470 | DHX36 | 170506 | 23 | 0 | 20 | |
| GSE46452 | DHX36 | 170506 | 18 | 2 | 39 | |
| GSE47630 | DHX36 | 170506 | 19 | 3 | 18 | |
| GSE54993 | DHX36 | 170506 | 1 | 10 | 59 | |
| GSE54994 | DHX36 | 170506 | 38 | 1 | 14 | |
| GSE60625 | DHX36 | 170506 | 0 | 6 | 5 | |
| GSE74703 | DHX36 | 170506 | 20 | 0 | 16 | |
| GSE74704 | DHX36 | 170506 | 14 | 0 | 6 | |
| TCGA | DHX36 | 170506 | 73 | 1 | 22 |
Total number of gains: 248; Total number of losses: 25; Total Number of normals: 215.
Somatic mutations of DHX36:
Generating mutation plots.
Highly correlated genes for DHX36:
Showing top 20/1495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHX36 | ALKBH6 | 0.823805 | 5 | 0 | 5 |
| DHX36 | PPP1R16A | 0.812446 | 3 | 0 | 3 |
| DHX36 | FIP1L1 | 0.810926 | 3 | 0 | 3 |
| DHX36 | U2SURP | 0.792071 | 6 | 0 | 6 |
| DHX36 | ZCCHC7 | 0.77893 | 3 | 0 | 3 |
| DHX36 | PTPN4 | 0.777193 | 5 | 0 | 4 |
| DHX36 | STRN4 | 0.768695 | 3 | 0 | 3 |
| DHX36 | MFHAS1 | 0.759419 | 6 | 0 | 6 |
| DHX36 | ZNF451 | 0.759223 | 4 | 0 | 4 |
| DHX36 | CIC | 0.755825 | 3 | 0 | 3 |
| DHX36 | EID2 | 0.751652 | 3 | 0 | 3 |
| DHX36 | C1orf35 | 0.751125 | 3 | 0 | 3 |
| DHX36 | STK3 | 0.748625 | 7 | 0 | 7 |
| DHX36 | GMPS | 0.747201 | 9 | 0 | 9 |
| DHX36 | CELF1 | 0.74208 | 5 | 0 | 4 |
| DHX36 | CEBPZ | 0.741723 | 5 | 0 | 5 |
| DHX36 | PKNOX1 | 0.739763 | 3 | 0 | 3 |
| DHX36 | RAD21 | 0.738228 | 5 | 0 | 5 |
| DHX36 | SNAPC2 | 0.737276 | 3 | 0 | 3 |
| DHX36 | SEL1L | 0.734041 | 3 | 0 | 3 |
For details and further investigation, click here
