PUF60

 

Full name: poly(U) binding splicing factor 60 Alias Symbol: FIR|SIAHBP1|RoBPI
Type: protein-coding gene Cytoband: 8q24.3
Entrez ID: 22827 HGNC ID: HGNC:17042 Ensembl Gene: ENSG00000179950 OMIM ID: 604819
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PUF60:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PUF60 22827 209899_s_at 0.8557 0.0181
GSE20347 PUF60 22827 209899_s_at 0.7663 0.0000
GSE23400 PUF60 22827 209899_s_at 0.7326 0.0000
GSE26886 PUF60 22827 209899_s_at 1.0878 0.0000
GSE29001 PUF60 22827 209899_s_at 0.6940 0.0024
GSE38129 PUF60 22827 209899_s_at 0.7089 0.0000
GSE45670 PUF60 22827 209899_s_at 0.5858 0.0029
GSE53622 PUF60 22827 91685 0.5285 0.0000
GSE53624 PUF60 22827 91685 0.8106 0.0000
GSE63941 PUF60 22827 209899_s_at 0.5646 0.2486
GSE77861 PUF60 22827 209899_s_at 0.6936 0.0072
GSE97050 PUF60 22827 A_24_P149645 0.3410 0.2423
SRP007169 PUF60 22827 RNAseq 0.1752 0.5371
SRP008496 PUF60 22827 RNAseq 0.3056 0.0817
SRP064894 PUF60 22827 RNAseq 1.0700 0.0001
SRP133303 PUF60 22827 RNAseq 0.5915 0.0000
SRP159526 PUF60 22827 RNAseq 0.6489 0.0104
SRP193095 PUF60 22827 RNAseq 0.6056 0.0000
SRP219564 PUF60 22827 RNAseq 0.5398 0.1669
TCGA PUF60 22827 RNAseq 0.2071 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by PUF60 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PUF60:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PUF60 22827 17 1 12
GSE20123 PUF60 22827 17 1 12
GSE43470 PUF60 22827 16 2 25
GSE46452 PUF60 22827 27 0 32
GSE47630 PUF60 22827 23 1 16
GSE54993 PUF60 22827 0 25 45
GSE54994 PUF60 22827 39 1 13
GSE60625 PUF60 22827 3 4 4
GSE74703 PUF60 22827 14 1 21
GSE74704 PUF60 22827 10 0 10
TCGA PUF60 22827 64 2 30

Total number of gains: 230; Total number of losses: 38; Total Number of normals: 220.  

 

Somatic mutations of PUF60:

 

Generating mutation plots.

 

Highly correlated genes for PUF60:

 

Showing top 20/2370 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PUF60ARFRP10.808294303
PUF60SLC25A320.80377311011
PUF60ATP6V1C10.80180811010
PUF60PFDN20.79094411011
PUF60TOP1MT0.788622908
PUF60EXOSC40.78521713013
PUF60LAPTM4B0.78478311011
PUF60TNFRSF1A0.784371303
PUF60RLIM0.78437303
PUF60WDR540.78319606
PUF60ATAD20.77530111011
PUF60TMEM63B0.774669404
PUF60PTDSS10.77346711011
PUF60SFR10.770749303
PUF60WDYHV10.76694812012
PUF60RBM260.76529303
PUF60ENY20.76387412012
PUF60PACSIN30.763555303
PUF60STK30.76184511011
PUF60FZD60.761207909

For details and further investigation, click here