| Full name: TP53 regulating kinase | Alias Symbol: dJ101A2.2|prpk|Nori-2p|BUD32 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 112858 | HGNC ID: HGNC:16197 | Ensembl Gene: ENSG00000172315 | OMIM ID: 608679 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TP53RK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TP53RK | 112858 | 225402_at | 1.0367 | 0.0396 | |
| GSE26886 | TP53RK | 112858 | 235192_at | -0.7341 | 0.0000 | |
| GSE45670 | TP53RK | 112858 | 225402_at | 0.4250 | 0.0178 | |
| GSE53622 | TP53RK | 112858 | 92533 | -0.2231 | 0.0069 | |
| GSE53624 | TP53RK | 112858 | 27358 | -0.0194 | 0.7790 | |
| GSE63941 | TP53RK | 112858 | 225402_at | 0.1682 | 0.7547 | |
| GSE77861 | TP53RK | 112858 | 235192_at | -0.1212 | 0.1905 | |
| GSE97050 | TP53RK | 112858 | A_23_P109055 | -0.2827 | 0.3442 | |
| SRP007169 | TP53RK | 112858 | RNAseq | -0.3572 | 0.3322 | |
| SRP008496 | TP53RK | 112858 | RNAseq | -0.0410 | 0.8833 | |
| SRP064894 | TP53RK | 112858 | RNAseq | 0.1564 | 0.4114 | |
| SRP133303 | TP53RK | 112858 | RNAseq | 0.1903 | 0.0655 | |
| SRP159526 | TP53RK | 112858 | RNAseq | 0.0511 | 0.8062 | |
| SRP193095 | TP53RK | 112858 | RNAseq | -0.1146 | 0.1368 | |
| SRP219564 | TP53RK | 112858 | RNAseq | 0.3083 | 0.2549 | |
| TCGA | TP53RK | 112858 | RNAseq | -0.0014 | 0.9803 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TP53RK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TP53RK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TP53RK | 112858 | 14 | 1 | 15 | |
| GSE20123 | TP53RK | 112858 | 14 | 1 | 15 | |
| GSE43470 | TP53RK | 112858 | 12 | 1 | 30 | |
| GSE46452 | TP53RK | 112858 | 29 | 0 | 30 | |
| GSE47630 | TP53RK | 112858 | 24 | 1 | 15 | |
| GSE54993 | TP53RK | 112858 | 0 | 18 | 52 | |
| GSE54994 | TP53RK | 112858 | 25 | 0 | 28 | |
| GSE60625 | TP53RK | 112858 | 0 | 0 | 11 | |
| GSE74703 | TP53RK | 112858 | 10 | 1 | 25 | |
| GSE74704 | TP53RK | 112858 | 10 | 0 | 10 | |
| TCGA | TP53RK | 112858 | 45 | 3 | 48 |
Total number of gains: 183; Total number of losses: 26; Total Number of normals: 279.
Somatic mutations of TP53RK:
Generating mutation plots.
Highly correlated genes for TP53RK:
Showing top 20/286 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TP53RK | MRPL13 | 0.830574 | 3 | 0 | 3 |
| TP53RK | MTFR1 | 0.825911 | 3 | 0 | 3 |
| TP53RK | POLR2K | 0.820977 | 3 | 0 | 3 |
| TP53RK | SCOC | 0.804364 | 3 | 0 | 3 |
| TP53RK | ATP6V1C1 | 0.795258 | 3 | 0 | 3 |
| TP53RK | EXOSC4 | 0.793238 | 3 | 0 | 3 |
| TP53RK | GLRX2 | 0.791944 | 3 | 0 | 3 |
| TP53RK | RALGAPB | 0.786197 | 3 | 0 | 3 |
| TP53RK | RRS1 | 0.784727 | 3 | 0 | 3 |
| TP53RK | MRPS28 | 0.783077 | 3 | 0 | 3 |
| TP53RK | SNRPB2 | 0.782446 | 3 | 0 | 3 |
| TP53RK | RLIM | 0.778509 | 3 | 0 | 3 |
| TP53RK | CNOT1 | 0.776758 | 3 | 0 | 3 |
| TP53RK | PPARGC1B | 0.773624 | 3 | 0 | 3 |
| TP53RK | MRPL3 | 0.772475 | 3 | 0 | 3 |
| TP53RK | AP1AR | 0.771931 | 3 | 0 | 3 |
| TP53RK | PRPF38A | 0.769938 | 3 | 0 | 3 |
| TP53RK | NUP153 | 0.765089 | 3 | 0 | 3 |
| TP53RK | GTF2H5 | 0.764351 | 3 | 0 | 3 |
| TP53RK | RAB3D | 0.763234 | 3 | 0 | 3 |
For details and further investigation, click here
