| Full name: transmembrane channel like 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q21.13 | ||
| Entrez ID: 117531 | HGNC ID: HGNC:16513 | Ensembl Gene: ENSG00000165091 | OMIM ID: 606706 |
| Drug and gene relationship at DGIdb | |||
Expression of TMC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMC1 | 117531 | 1564591_a_at | 0.0269 | 0.9343 | |
| GSE26886 | TMC1 | 117531 | 1564591_a_at | -0.1815 | 0.1197 | |
| GSE45670 | TMC1 | 117531 | 1564591_a_at | 0.1094 | 0.2378 | |
| GSE53622 | TMC1 | 117531 | 19885 | 0.4109 | 0.0314 | |
| GSE53624 | TMC1 | 117531 | 75735 | 0.3286 | 0.0000 | |
| GSE63941 | TMC1 | 117531 | 1564591_a_at | 0.0768 | 0.6877 | |
| GSE77861 | TMC1 | 117531 | 1564591_a_at | -0.1143 | 0.2737 | |
| SRP007169 | TMC1 | 117531 | RNAseq | -3.1748 | 0.0000 | |
| SRP064894 | TMC1 | 117531 | RNAseq | -3.1342 | 0.0000 | |
| SRP133303 | TMC1 | 117531 | RNAseq | -1.2161 | 0.0277 | |
| SRP159526 | TMC1 | 117531 | RNAseq | -2.9154 | 0.0001 | |
| TCGA | TMC1 | 117531 | RNAseq | 2.7882 | 0.0009 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by TMC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMC1 | 117531 | 6 | 10 | 14 | |
| GSE20123 | TMC1 | 117531 | 6 | 10 | 14 | |
| GSE43470 | TMC1 | 117531 | 6 | 5 | 32 | |
| GSE46452 | TMC1 | 117531 | 6 | 14 | 39 | |
| GSE47630 | TMC1 | 117531 | 1 | 18 | 21 | |
| GSE54993 | TMC1 | 117531 | 4 | 1 | 65 | |
| GSE54994 | TMC1 | 117531 | 4 | 13 | 36 | |
| GSE60625 | TMC1 | 117531 | 0 | 0 | 11 | |
| GSE74703 | TMC1 | 117531 | 5 | 4 | 27 | |
| GSE74704 | TMC1 | 117531 | 3 | 8 | 9 | |
| TCGA | TMC1 | 117531 | 19 | 27 | 50 |
Total number of gains: 60; Total number of losses: 110; Total Number of normals: 318.
Somatic mutations of TMC1:
Generating mutation plots.
Highly correlated genes for TMC1:
Showing top 20/38 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMC1 | ISM1-AS1 | 0.694551 | 3 | 0 | 3 |
| TMC1 | KCNA4 | 0.64841 | 3 | 0 | 3 |
| TMC1 | MAGI1-IT1 | 0.62691 | 3 | 0 | 3 |
| TMC1 | PRR29 | 0.617258 | 4 | 0 | 4 |
| TMC1 | TMEM132B | 0.606904 | 3 | 0 | 3 |
| TMC1 | TLR8-AS1 | 0.594037 | 4 | 0 | 3 |
| TMC1 | FAM209B | 0.593177 | 3 | 0 | 3 |
| TMC1 | MED12L | 0.588422 | 4 | 0 | 4 |
| TMC1 | CCDC170 | 0.587866 | 4 | 0 | 3 |
| TMC1 | MRGPRG-AS1 | 0.579929 | 3 | 0 | 3 |
| TMC1 | SOX14 | 0.57906 | 3 | 0 | 3 |
| TMC1 | LINC00167 | 0.577528 | 4 | 0 | 3 |
| TMC1 | NAV2-IT1 | 0.575151 | 4 | 0 | 3 |
| TMC1 | ZBTB20-AS1 | 0.573917 | 4 | 0 | 3 |
| TMC1 | VGLL2 | 0.572622 | 4 | 0 | 4 |
| TMC1 | SIGLEC6 | 0.569323 | 4 | 0 | 3 |
| TMC1 | FGF5 | 0.567745 | 4 | 0 | 3 |
| TMC1 | ARMC4 | 0.567218 | 4 | 0 | 3 |
| TMC1 | NPTXR | 0.56391 | 3 | 0 | 3 |
| TMC1 | C1orf158 | 0.561793 | 3 | 0 | 3 |
For details and further investigation, click here
