| Full name: sialic acid binding Ig like lectin 6 | Alias Symbol: OB-BP1|SIGLEC-6|CD327 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 946 | HGNC ID: HGNC:10875 | Ensembl Gene: ENSG00000105492 | OMIM ID: 604405 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC6 | 946 | 206520_x_at | -0.1646 | 0.6041 | |
| GSE20347 | SIGLEC6 | 946 | 206520_x_at | 0.0757 | 0.5353 | |
| GSE23400 | SIGLEC6 | 946 | 206520_x_at | -0.1382 | 0.0050 | |
| GSE26886 | SIGLEC6 | 946 | 206520_x_at | -0.3207 | 0.0122 | |
| GSE29001 | SIGLEC6 | 946 | 206520_x_at | -0.0986 | 0.3783 | |
| GSE38129 | SIGLEC6 | 946 | 206520_x_at | -0.0959 | 0.3778 | |
| GSE45670 | SIGLEC6 | 946 | 206520_x_at | 0.1189 | 0.1936 | |
| GSE63941 | SIGLEC6 | 946 | 206520_x_at | 0.3078 | 0.0706 | |
| GSE77861 | SIGLEC6 | 946 | 206520_x_at | -0.1467 | 0.1596 | |
| GSE97050 | SIGLEC6 | 946 | A_23_P4592 | 0.0752 | 0.7673 | |
| SRP007169 | SIGLEC6 | 946 | RNAseq | -0.5805 | 0.3322 | |
| SRP064894 | SIGLEC6 | 946 | RNAseq | -1.0774 | 0.0035 | |
| SRP133303 | SIGLEC6 | 946 | RNAseq | -1.2939 | 0.0000 | |
| SRP159526 | SIGLEC6 | 946 | RNAseq | -0.4722 | 0.5308 | |
| SRP193095 | SIGLEC6 | 946 | RNAseq | -0.3011 | 0.0684 | |
| SRP219564 | SIGLEC6 | 946 | RNAseq | 0.2846 | 0.5524 | |
| TCGA | SIGLEC6 | 946 | RNAseq | -1.6091 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SIGLEC6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC6 | 946 | 3 | 4 | 23 | |
| GSE20123 | SIGLEC6 | 946 | 3 | 3 | 24 | |
| GSE43470 | SIGLEC6 | 946 | 3 | 12 | 28 | |
| GSE46452 | SIGLEC6 | 946 | 45 | 1 | 13 | |
| GSE47630 | SIGLEC6 | 946 | 10 | 6 | 24 | |
| GSE54993 | SIGLEC6 | 946 | 17 | 4 | 49 | |
| GSE54994 | SIGLEC6 | 946 | 4 | 14 | 35 | |
| GSE60625 | SIGLEC6 | 946 | 9 | 0 | 2 | |
| GSE74703 | SIGLEC6 | 946 | 3 | 8 | 25 | |
| GSE74704 | SIGLEC6 | 946 | 3 | 1 | 16 | |
| TCGA | SIGLEC6 | 946 | 14 | 19 | 63 |
Total number of gains: 114; Total number of losses: 72; Total Number of normals: 302.
Somatic mutations of SIGLEC6:
Generating mutation plots.
Highly correlated genes for SIGLEC6:
Showing top 20/896 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC6 | BCAN | 0.738268 | 6 | 0 | 6 |
| SIGLEC6 | FAM71F2 | 0.733669 | 3 | 0 | 3 |
| SIGLEC6 | ADARB2-AS1 | 0.723786 | 4 | 0 | 4 |
| SIGLEC6 | ZNF548 | 0.715869 | 3 | 0 | 3 |
| SIGLEC6 | CDC25C | 0.708808 | 3 | 0 | 3 |
| SIGLEC6 | NTNG1 | 0.704479 | 4 | 0 | 4 |
| SIGLEC6 | CCIN | 0.699199 | 4 | 0 | 4 |
| SIGLEC6 | EPHA5 | 0.699023 | 4 | 0 | 4 |
| SIGLEC6 | GTF2H3 | 0.697132 | 3 | 0 | 3 |
| SIGLEC6 | CHRM5 | 0.691199 | 6 | 0 | 6 |
| SIGLEC6 | MED24 | 0.68704 | 6 | 0 | 5 |
| SIGLEC6 | AMOTL2 | 0.684686 | 4 | 0 | 3 |
| SIGLEC6 | LINC00315 | 0.683886 | 3 | 0 | 3 |
| SIGLEC6 | SLC17A1 | 0.683132 | 5 | 0 | 5 |
| SIGLEC6 | NPTXR | 0.683112 | 5 | 0 | 5 |
| SIGLEC6 | VAX2 | 0.682494 | 4 | 0 | 4 |
| SIGLEC6 | CIITA | 0.682461 | 5 | 0 | 4 |
| SIGLEC6 | GPR31 | 0.681644 | 5 | 0 | 4 |
| SIGLEC6 | NCR2 | 0.681366 | 8 | 0 | 7 |
| SIGLEC6 | FOXP3 | 0.680665 | 5 | 0 | 5 |
For details and further investigation, click here
