| Full name: mediator complex subunit 12L | Alias Symbol: KIAA1635|TNRC11L|TRALPUSH|TRALP | ||
| Type: protein-coding gene | Cytoband: 3q25.1 | ||
| Entrez ID: 116931 | HGNC ID: HGNC:16050 | Ensembl Gene: ENSG00000144893 | OMIM ID: 611318 |
| Drug and gene relationship at DGIdb | |||
Expression of MED12L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED12L | 116931 | 1555300_a_at | -0.0224 | 0.9248 | |
| GSE26886 | MED12L | 116931 | 1555300_a_at | -0.1370 | 0.2216 | |
| GSE45670 | MED12L | 116931 | 1555300_a_at | 0.2282 | 0.0312 | |
| GSE53622 | MED12L | 116931 | 163919 | 0.9061 | 0.0000 | |
| GSE53624 | MED12L | 116931 | 64633 | 0.5983 | 0.0006 | |
| GSE63941 | MED12L | 116931 | 1555300_a_at | 0.2187 | 0.2816 | |
| GSE77861 | MED12L | 116931 | 1555300_a_at | -0.1406 | 0.2857 | |
| GSE97050 | MED12L | 116931 | A_33_P3259725 | 0.1486 | 0.5294 | |
| SRP007169 | MED12L | 116931 | RNAseq | 3.8990 | 0.0001 | |
| SRP133303 | MED12L | 116931 | RNAseq | 0.4399 | 0.1907 | |
| SRP159526 | MED12L | 116931 | RNAseq | 2.0002 | 0.0000 | |
| SRP193095 | MED12L | 116931 | RNAseq | 0.8611 | 0.0002 | |
| TCGA | MED12L | 116931 | RNAseq | 1.5512 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MED12L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED12L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED12L | 116931 | 21 | 0 | 9 | |
| GSE20123 | MED12L | 116931 | 21 | 0 | 9 | |
| GSE43470 | MED12L | 116931 | 23 | 0 | 20 | |
| GSE46452 | MED12L | 116931 | 18 | 2 | 39 | |
| GSE47630 | MED12L | 116931 | 19 | 3 | 18 | |
| GSE54993 | MED12L | 116931 | 1 | 10 | 59 | |
| GSE54994 | MED12L | 116931 | 37 | 1 | 15 | |
| GSE60625 | MED12L | 116931 | 0 | 6 | 5 | |
| GSE74703 | MED12L | 116931 | 20 | 0 | 16 | |
| GSE74704 | MED12L | 116931 | 14 | 0 | 6 | |
| TCGA | MED12L | 116931 | 72 | 1 | 23 |
Total number of gains: 246; Total number of losses: 23; Total Number of normals: 219.
Somatic mutations of MED12L:
Generating mutation plots.
Highly correlated genes for MED12L:
Showing top 20/39 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED12L | ERCC8 | 0.668429 | 3 | 0 | 3 |
| MED12L | GPR37L1 | 0.667801 | 3 | 0 | 3 |
| MED12L | LCE2B | 0.654786 | 3 | 0 | 3 |
| MED12L | NFKBIL1 | 0.636645 | 3 | 0 | 3 |
| MED12L | KRT37 | 0.624469 | 3 | 0 | 3 |
| MED12L | CD163L1 | 0.61746 | 3 | 0 | 3 |
| MED12L | ACY1 | 0.616272 | 3 | 0 | 3 |
| MED12L | ADAMTS18 | 0.614203 | 3 | 0 | 3 |
| MED12L | RNF185-AS1 | 0.602185 | 3 | 0 | 3 |
| MED12L | OLFM2 | 0.598581 | 3 | 0 | 3 |
| MED12L | IDH3A | 0.595587 | 3 | 0 | 3 |
| MED12L | LINC01281 | 0.59169 | 4 | 0 | 3 |
| MED12L | GPR15 | 0.590064 | 4 | 0 | 3 |
| MED12L | TMC1 | 0.588422 | 4 | 0 | 4 |
| MED12L | TMEM150B | 0.58687 | 4 | 0 | 3 |
| MED12L | ALG10 | 0.585729 | 3 | 0 | 3 |
| MED12L | FLVCR2 | 0.581241 | 4 | 0 | 3 |
| MED12L | CEACAM3 | 0.579543 | 3 | 0 | 3 |
| MED12L | LILRA2 | 0.576121 | 3 | 0 | 3 |
| MED12L | MPP4 | 0.567887 | 3 | 0 | 3 |
For details and further investigation, click here
