| Full name: ceramide synthase 1 | Alias Symbol: LAG1|UOG1 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 10715 | HGNC ID: HGNC:14253 | Ensembl Gene: ENSG00000223802 | OMIM ID: 606919 |
| Drug and gene relationship at DGIdb | |||
Expression of CERS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CERS1 | 10715 | 17655 | -0.0397 | 0.8865 | |
| GSE53624 | CERS1 | 10715 | 17655 | 0.4946 | 0.0079 | |
| GSE97050 | CERS1 | 10715 | A_33_P3408320 | -0.1759 | 0.4585 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CERS1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of CERS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CERS1 | 10715 | 4 | 5 | 21 | |
| GSE20123 | CERS1 | 10715 | 3 | 3 | 24 | |
| GSE43470 | CERS1 | 10715 | 2 | 5 | 36 | |
| GSE46452 | CERS1 | 10715 | 47 | 1 | 11 | |
| GSE47630 | CERS1 | 10715 | 5 | 8 | 27 | |
| GSE54993 | CERS1 | 10715 | 16 | 4 | 50 | |
| GSE54994 | CERS1 | 10715 | 6 | 13 | 34 | |
| GSE60625 | CERS1 | 10715 | 9 | 0 | 2 | |
| GSE74703 | CERS1 | 10715 | 2 | 3 | 31 | |
| GSE74704 | CERS1 | 10715 | 0 | 3 | 17 | |
| TCGA | CERS1 | 10715 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of CERS1:
Generating mutation plots.
Highly correlated genes for CERS1:
Showing all 11 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CERS1 | NRXN2 | 0.701722 | 3 | 0 | 3 |
| CERS1 | KIF5C | 0.649847 | 3 | 0 | 3 |
| CERS1 | KLHL23 | 0.643581 | 3 | 0 | 3 |
| CERS1 | REEP2 | 0.639669 | 3 | 0 | 3 |
| CERS1 | TMEM121 | 0.608405 | 3 | 0 | 3 |
| CERS1 | CTSF | 0.608247 | 3 | 0 | 3 |
| CERS1 | C12orf57 | 0.567242 | 3 | 0 | 3 |
| CERS1 | RBM12 | 0.564113 | 3 | 0 | 3 |
| CERS1 | KHDRBS3 | 0.55266 | 3 | 0 | 3 |
| CERS1 | YPEL1 | 0.545009 | 3 | 0 | 3 |
| CERS1 | CENPV | 0.529042 | 3 | 0 | 3 |
For details and further investigation, click here
