| Full name: transmembrane protein 121 | Alias Symbol: MGC4659|hole|TMEM121A | ||
| Type: protein-coding gene | Cytoband: 14q32.33 | ||
| Entrez ID: 80757 | HGNC ID: HGNC:20511 | Ensembl Gene: ENSG00000184986 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM121:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM121 | 80757 | 219663_s_at | 0.4040 | 0.3619 | |
| GSE20347 | TMEM121 | 80757 | 219663_s_at | 0.1019 | 0.1126 | |
| GSE23400 | TMEM121 | 80757 | 219663_s_at | -0.0300 | 0.5725 | |
| GSE26886 | TMEM121 | 80757 | 219663_s_at | 0.7070 | 0.0000 | |
| GSE29001 | TMEM121 | 80757 | 219663_s_at | 0.0425 | 0.8749 | |
| GSE38129 | TMEM121 | 80757 | 219663_s_at | 0.0581 | 0.4580 | |
| GSE45670 | TMEM121 | 80757 | 219663_s_at | -0.0973 | 0.3497 | |
| GSE53622 | TMEM121 | 80757 | 4400 | 0.7575 | 0.0000 | |
| GSE53624 | TMEM121 | 80757 | 4400 | 1.0431 | 0.0000 | |
| GSE63941 | TMEM121 | 80757 | 219663_s_at | 0.1245 | 0.7741 | |
| GSE77861 | TMEM121 | 80757 | 222914_s_at | -0.2113 | 0.0754 | |
| GSE97050 | TMEM121 | 80757 | A_33_P3411632 | 0.2193 | 0.4583 | |
| SRP133303 | TMEM121 | 80757 | RNAseq | 0.5950 | 0.0697 | |
| SRP159526 | TMEM121 | 80757 | RNAseq | 1.6334 | 0.0360 | |
| SRP219564 | TMEM121 | 80757 | RNAseq | 0.6354 | 0.3371 | |
| TCGA | TMEM121 | 80757 | RNAseq | 0.1125 | 0.5658 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TMEM121 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM121:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM121 | 80757 | 10 | 3 | 17 | |
| GSE20123 | TMEM121 | 80757 | 10 | 2 | 18 | |
| GSE43470 | TMEM121 | 80757 | 5 | 3 | 35 | |
| GSE46452 | TMEM121 | 80757 | 18 | 4 | 37 | |
| GSE47630 | TMEM121 | 80757 | 10 | 10 | 20 | |
| GSE54993 | TMEM121 | 80757 | 4 | 11 | 55 | |
| GSE54994 | TMEM121 | 80757 | 21 | 4 | 28 | |
| GSE60625 | TMEM121 | 80757 | 0 | 2 | 9 | |
| GSE74703 | TMEM121 | 80757 | 4 | 3 | 29 | |
| GSE74704 | TMEM121 | 80757 | 5 | 2 | 13 | |
| TCGA | TMEM121 | 80757 | 31 | 18 | 47 |
Total number of gains: 118; Total number of losses: 62; Total Number of normals: 308.
Somatic mutations of TMEM121:
Generating mutation plots.
Highly correlated genes for TMEM121:
Showing top 20/385 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM121 | ZNF628 | 0.747413 | 3 | 0 | 3 |
| TMEM121 | SLC39A3 | 0.725046 | 3 | 0 | 3 |
| TMEM121 | MZF1 | 0.724333 | 3 | 0 | 3 |
| TMEM121 | RAB34 | 0.723539 | 3 | 0 | 3 |
| TMEM121 | CLDND2 | 0.699529 | 3 | 0 | 3 |
| TMEM121 | ITGB3 | 0.699027 | 4 | 0 | 4 |
| TMEM121 | GRWD1 | 0.691237 | 4 | 0 | 3 |
| TMEM121 | TBC1D25 | 0.690012 | 4 | 0 | 4 |
| TMEM121 | NAP1L5 | 0.687212 | 3 | 0 | 3 |
| TMEM121 | SLC35B2 | 0.68569 | 3 | 0 | 3 |
| TMEM121 | SPATA5 | 0.680587 | 3 | 0 | 3 |
| TMEM121 | GGN | 0.676246 | 3 | 0 | 3 |
| TMEM121 | ACOXL | 0.671982 | 3 | 0 | 3 |
| TMEM121 | ROMO1 | 0.671342 | 3 | 0 | 3 |
| TMEM121 | ZNF362 | 0.669558 | 4 | 0 | 3 |
| TMEM121 | TNFRSF4 | 0.6692 | 5 | 0 | 4 |
| TMEM121 | FCRLA | 0.666406 | 3 | 0 | 3 |
| TMEM121 | SUSD3 | 0.665051 | 4 | 0 | 4 |
| TMEM121 | PITX2 | 0.662123 | 3 | 0 | 3 |
| TMEM121 | MATN4 | 0.66147 | 5 | 0 | 5 |
For details and further investigation, click here
