| Full name: kinesin family member 5C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q23.1-q23.2 | ||
| Entrez ID: 3800 | HGNC ID: HGNC:6325 | Ensembl Gene: ENSG00000168280 | OMIM ID: 604593 |
| Drug and gene relationship at DGIdb | |||
KIF5C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04728 | Dopaminergic synapse |
Expression of KIF5C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIF5C | 3800 | 203130_s_at | -0.2557 | 0.8241 | |
| GSE20347 | KIF5C | 3800 | 203129_s_at | -0.0962 | 0.3192 | |
| GSE23400 | KIF5C | 3800 | 203130_s_at | -0.2388 | 0.0000 | |
| GSE26886 | KIF5C | 3800 | 203130_s_at | 0.3160 | 0.1228 | |
| GSE29001 | KIF5C | 3800 | 203130_s_at | 0.1194 | 0.6864 | |
| GSE38129 | KIF5C | 3800 | 203129_s_at | -0.3260 | 0.0456 | |
| GSE45670 | KIF5C | 3800 | 203130_s_at | -0.8364 | 0.0550 | |
| GSE53622 | KIF5C | 3800 | 57562 | -0.6470 | 0.0009 | |
| GSE53624 | KIF5C | 3800 | 11926 | -0.1471 | 0.4119 | |
| GSE63941 | KIF5C | 3800 | 203130_s_at | 0.3955 | 0.3413 | |
| GSE77861 | KIF5C | 3800 | 1557089_at | -0.0220 | 0.8965 | |
| GSE97050 | KIF5C | 3800 | A_32_P154473 | -0.8905 | 0.2501 | |
| SRP064894 | KIF5C | 3800 | RNAseq | 0.0190 | 0.9553 | |
| SRP133303 | KIF5C | 3800 | RNAseq | -0.5920 | 0.0476 | |
| SRP159526 | KIF5C | 3800 | RNAseq | 1.5167 | 0.0312 | |
| SRP193095 | KIF5C | 3800 | RNAseq | -0.2489 | 0.3804 | |
| TCGA | KIF5C | 3800 | RNAseq | -1.1138 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by KIF5C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIF5C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIF5C | 3800 | 3 | 3 | 24 | |
| GSE20123 | KIF5C | 3800 | 3 | 3 | 24 | |
| GSE43470 | KIF5C | 3800 | 3 | 1 | 39 | |
| GSE46452 | KIF5C | 3800 | 1 | 4 | 54 | |
| GSE47630 | KIF5C | 3800 | 5 | 3 | 32 | |
| GSE54993 | KIF5C | 3800 | 0 | 5 | 65 | |
| GSE54994 | KIF5C | 3800 | 11 | 2 | 40 | |
| GSE60625 | KIF5C | 3800 | 0 | 3 | 8 | |
| GSE74703 | KIF5C | 3800 | 2 | 1 | 33 | |
| GSE74704 | KIF5C | 3800 | 3 | 1 | 16 | |
| TCGA | KIF5C | 3800 | 23 | 8 | 65 |
Total number of gains: 54; Total number of losses: 34; Total Number of normals: 400.
Somatic mutations of KIF5C:
Generating mutation plots.
Highly correlated genes for KIF5C:
Showing top 20/783 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIF5C | ANO6 | 0.779571 | 3 | 0 | 3 |
| KIF5C | IGIP | 0.768691 | 3 | 0 | 3 |
| KIF5C | TECPR2 | 0.759976 | 3 | 0 | 3 |
| KIF5C | SEMA3A | 0.742354 | 5 | 0 | 5 |
| KIF5C | KATNAL1 | 0.741553 | 4 | 0 | 4 |
| KIF5C | PLIN4 | 0.737416 | 4 | 0 | 4 |
| KIF5C | SH3GL2 | 0.731355 | 9 | 0 | 9 |
| KIF5C | PCDH9 | 0.728917 | 6 | 0 | 5 |
| KIF5C | LSM11 | 0.728585 | 4 | 0 | 4 |
| KIF5C | MACF1 | 0.72702 | 3 | 0 | 3 |
| KIF5C | S1PR3 | 0.725526 | 4 | 0 | 4 |
| KIF5C | TPPP | 0.725461 | 3 | 0 | 3 |
| KIF5C | SMAD4 | 0.718395 | 4 | 0 | 4 |
| KIF5C | PYGM | 0.715362 | 6 | 0 | 6 |
| KIF5C | CYP2U1 | 0.714904 | 6 | 0 | 6 |
| KIF5C | C1orf21 | 0.712605 | 3 | 0 | 3 |
| KIF5C | POU6F1 | 0.707138 | 4 | 0 | 4 |
| KIF5C | ZNF25 | 0.704853 | 4 | 0 | 4 |
| KIF5C | TNFSF12 | 0.704467 | 3 | 0 | 3 |
| KIF5C | TMOD1 | 0.70319 | 6 | 0 | 5 |
For details and further investigation, click here
