CHD4

 

Full name: chromodomain helicase DNA binding protein 4 Alias Symbol: Mi-2b|Mi2-BETA
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 1108 HGNC ID: HGNC:1919 Ensembl Gene: ENSG00000111642 OMIM ID: 603277
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 90/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CHD4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CHD4 1108 201184_s_at 0.3966 0.1520
GSE20347 CHD4 1108 201184_s_at 0.2262 0.0176
GSE23400 CHD4 1108 201184_s_at 0.0765 0.0913
GSE26886 CHD4 1108 201184_s_at 0.6564 0.0004
GSE29001 CHD4 1108 201184_s_at 0.1070 0.5613
GSE38129 CHD4 1108 201184_s_at 0.1675 0.2002
GSE45670 CHD4 1108 201184_s_at 0.1606 0.1901
GSE53622 CHD4 1108 16093 0.4053 0.0000
GSE53624 CHD4 1108 16093 0.4119 0.0000
GSE63941 CHD4 1108 201184_s_at -0.1280 0.6456
GSE77861 CHD4 1108 201184_s_at 0.3203 0.0329
GSE97050 CHD4 1108 A_23_P53541 0.1994 0.4447
SRP007169 CHD4 1108 RNAseq 1.0122 0.0300
SRP008496 CHD4 1108 RNAseq 0.9748 0.0004
SRP064894 CHD4 1108 RNAseq 0.3028 0.0184
SRP133303 CHD4 1108 RNAseq 0.4069 0.0001
SRP159526 CHD4 1108 RNAseq 0.2608 0.2607
SRP193095 CHD4 1108 RNAseq 0.3140 0.0003
SRP219564 CHD4 1108 RNAseq 0.0024 0.9910
TCGA CHD4 1108 RNAseq -0.0014 0.9707

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CHD4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CHD4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CHD4 1108 9 4 17
GSE20123 CHD4 1108 9 4 17
GSE43470 CHD4 1108 8 3 32
GSE46452 CHD4 1108 10 1 48
GSE47630 CHD4 1108 12 2 26
GSE54993 CHD4 1108 1 10 59
GSE54994 CHD4 1108 10 2 41
GSE60625 CHD4 1108 0 1 10
GSE74703 CHD4 1108 7 2 27
GSE74704 CHD4 1108 5 3 12
TCGA CHD4 1108 40 6 50

Total number of gains: 111; Total number of losses: 38; Total Number of normals: 339.  

 

Somatic mutations of CHD4:

 

Generating mutation plots.

 

Highly correlated genes for CHD4:

 

Showing top 20/1481 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CHD4ZBED10.855921303
CHD4PIGU0.830891303
CHD4ZBTB90.823612303
CHD4MDM20.805224303
CHD4ZBED40.79755303
CHD4TFIP110.79231303
CHD4C12orf730.783505303
CHD4DNAJC90.776437303
CHD4MED260.774682303
CHD4RNF1300.774207404
CHD4PDRG10.766327303
CHD4MSL10.762712303
CHD4ZNF8050.759205303
CHD4GPR1580.757767404
CHD4ZBTB440.751931303
CHD4ZMYND190.751642303
CHD4RALGAPA20.750227303
CHD4TEX100.749057303
CHD4COMMD70.745368403
CHD4ZNF5670.73849303

For details and further investigation, click here