MDM2

 

Full name: MDM2 proto-oncogene Alias Symbol: HDM2|MGC5370
Type: protein-coding gene Cytoband: 12q15
Entrez ID: 4193 HGNC ID: HGNC:6973 Ensembl Gene: ENSG00000135679 OMIM ID: 164785
Drug and gene relationship at DGIdb
Screen Evidence:

 

MDM2 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia

 

Expression of MDM2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MDM2 4193 229711_s_at 0.5203 0.3206
GSE20347 MDM2 4193 217542_at -0.2273 0.0424
GSE23400 MDM2 4193 205385_at 0.0109 0.7332
GSE26886 MDM2 4193 229711_s_at 0.6188 0.0014
GSE29001 MDM2 4193 217542_at -0.0224 0.9539
GSE38129 MDM2 4193 217542_at -0.0449 0.7516
GSE45670 MDM2 4193 229711_s_at 0.2441 0.1054
GSE53622 MDM2 4193 67431 0.1988 0.0015
GSE53624 MDM2 4193 67431 -0.4095 0.0000
GSE63941 MDM2 4193 229711_s_at -0.9846 0.1349
GSE77861 MDM2 4193 229711_s_at 0.0824 0.7539
GSE97050 MDM2 4193 A_33_P3361707 0.2860 0.2027
SRP007169 MDM2 4193 RNAseq 0.2691 0.4697
SRP008496 MDM2 4193 RNAseq 0.3716 0.0710
SRP064894 MDM2 4193 RNAseq 0.1365 0.5685
SRP133303 MDM2 4193 RNAseq 0.2158 0.1343
SRP159526 MDM2 4193 RNAseq 0.3473 0.1162
SRP193095 MDM2 4193 RNAseq -0.1133 0.3073
SRP219564 MDM2 4193 RNAseq 1.3389 0.0508
TCGA MDM2 4193 RNAseq 0.0114 0.8724

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MDM2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MDM2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MDM2 4193 6 1 23
GSE20123 MDM2 4193 6 0 24
GSE43470 MDM2 4193 5 0 38
GSE46452 MDM2 4193 12 0 47
GSE47630 MDM2 4193 10 1 29
GSE54993 MDM2 4193 0 7 63
GSE54994 MDM2 4193 7 1 45
GSE60625 MDM2 4193 0 0 11
GSE74703 MDM2 4193 5 0 31
GSE74704 MDM2 4193 5 0 15
TCGA MDM2 4193 23 8 65

Total number of gains: 79; Total number of losses: 18; Total Number of normals: 391.  

 

Somatic mutations of MDM2:

 

Generating mutation plots.

 

Highly correlated genes for MDM2:

 

Showing top 20/199 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MDM2TRMT60.827312303
MDM2CHD40.805224303
MDM2PFAS0.797949303
MDM2RPP400.781304303
MDM2MGAT4B0.776689303
MDM2HNRNPR0.776313303
MDM2SRPK10.77567303
MDM2BAG40.775261303
MDM2SEC22A0.764607303
MDM2NUP1530.758586303
MDM2PAIP10.751875303
MDM2NUP540.751116404
MDM2ANKIB10.747745303
MDM2TBL20.744773303
MDM2PHTF20.742619303
MDM2NHS0.735473303
MDM2STX60.734366404
MDM2KIAA18410.73272303
MDM2HERC40.726423303
MDM2SRP720.724421303

For details and further investigation, click here