| Full name: MSL complex subunit 1 | Alias Symbol: hMSL1|MSL-1|DKFZp686P24239 | ||
| Type: protein-coding gene | Cytoband: 17q21.1 | ||
| Entrez ID: 339287 | HGNC ID: HGNC:27905 | Ensembl Gene: ENSG00000188895 | OMIM ID: 614801 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MSL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MSL1 | 339287 | 212708_at | -0.0232 | 0.9548 | |
| GSE20347 | MSL1 | 339287 | 212708_at | -0.3671 | 0.0047 | |
| GSE23400 | MSL1 | 339287 | 212708_at | -0.1326 | 0.1067 | |
| GSE26886 | MSL1 | 339287 | 224765_at | -0.6311 | 0.0115 | |
| GSE29001 | MSL1 | 339287 | 212708_at | -0.1130 | 0.5855 | |
| GSE38129 | MSL1 | 339287 | 212708_at | -0.3268 | 0.0033 | |
| GSE45670 | MSL1 | 339287 | 224765_at | 0.1442 | 0.2968 | |
| GSE53622 | MSL1 | 339287 | 42840 | 0.5235 | 0.0000 | |
| GSE53624 | MSL1 | 339287 | 83685 | -0.4151 | 0.0000 | |
| GSE63941 | MSL1 | 339287 | 224765_at | -0.1569 | 0.6959 | |
| GSE77861 | MSL1 | 339287 | 224765_at | 0.6922 | 0.0182 | |
| GSE97050 | MSL1 | 339287 | A_33_P3356341 | 0.4299 | 0.2706 | |
| SRP007169 | MSL1 | 339287 | RNAseq | -0.0880 | 0.7990 | |
| SRP008496 | MSL1 | 339287 | RNAseq | -0.2014 | 0.2724 | |
| SRP064894 | MSL1 | 339287 | RNAseq | 0.0386 | 0.7713 | |
| SRP133303 | MSL1 | 339287 | RNAseq | -0.0289 | 0.7703 | |
| SRP159526 | MSL1 | 339287 | RNAseq | -0.1332 | 0.5591 | |
| SRP193095 | MSL1 | 339287 | RNAseq | 0.0372 | 0.6201 | |
| SRP219564 | MSL1 | 339287 | RNAseq | -0.5241 | 0.0604 | |
| TCGA | MSL1 | 339287 | RNAseq | 0.0574 | 0.2223 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MSL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MSL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MSL1 | 339287 | 8 | 1 | 21 | |
| GSE20123 | MSL1 | 339287 | 8 | 1 | 21 | |
| GSE43470 | MSL1 | 339287 | 1 | 2 | 40 | |
| GSE46452 | MSL1 | 339287 | 34 | 0 | 25 | |
| GSE47630 | MSL1 | 339287 | 8 | 1 | 31 | |
| GSE54993 | MSL1 | 339287 | 3 | 4 | 63 | |
| GSE54994 | MSL1 | 339287 | 8 | 5 | 40 | |
| GSE60625 | MSL1 | 339287 | 4 | 0 | 7 | |
| GSE74703 | MSL1 | 339287 | 1 | 1 | 34 | |
| GSE74704 | MSL1 | 339287 | 5 | 1 | 14 | |
| TCGA | MSL1 | 339287 | 23 | 8 | 65 |
Total number of gains: 103; Total number of losses: 24; Total Number of normals: 361.
Somatic mutations of MSL1:
Generating mutation plots.
Highly correlated genes for MSL1:
Showing top 20/169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MSL1 | CHD4 | 0.762712 | 3 | 0 | 3 |
| MSL1 | YLPM1 | 0.746793 | 3 | 0 | 3 |
| MSL1 | TMEM138 | 0.746496 | 3 | 0 | 3 |
| MSL1 | MDN1 | 0.739674 | 3 | 0 | 3 |
| MSL1 | NR1H3 | 0.733419 | 3 | 0 | 3 |
| MSL1 | DYNC1LI2 | 0.731722 | 3 | 0 | 3 |
| MSL1 | SAMM50 | 0.730202 | 3 | 0 | 3 |
| MSL1 | FAM50A | 0.726532 | 3 | 0 | 3 |
| MSL1 | WDR92 | 0.726217 | 3 | 0 | 3 |
| MSL1 | ZBED1 | 0.724023 | 3 | 0 | 3 |
| MSL1 | UPF1 | 0.715601 | 3 | 0 | 3 |
| MSL1 | TMEM218 | 0.71155 | 4 | 0 | 4 |
| MSL1 | TMTC4 | 0.704895 | 3 | 0 | 3 |
| MSL1 | THOC6 | 0.701522 | 3 | 0 | 3 |
| MSL1 | SNF8 | 0.688881 | 4 | 0 | 4 |
| MSL1 | POGZ | 0.684179 | 3 | 0 | 3 |
| MSL1 | FYTTD1 | 0.683906 | 3 | 0 | 3 |
| MSL1 | LDLR | 0.681594 | 3 | 0 | 3 |
| MSL1 | RHBDD2 | 0.681172 | 3 | 0 | 3 |
| MSL1 | VPS39 | 0.679415 | 4 | 0 | 3 |
For details and further investigation, click here
