DCLK3

 

Full name: doublecortin like kinase 3 Alias Symbol: KIAA1765|DCDC3C
Type: protein-coding gene Cytoband: 3p22.2
Entrez ID: 85443 HGNC ID: HGNC:19005 Ensembl Gene: ENSG00000163673 OMIM ID: 613167
Drug and gene relationship at DGIdb

 

Expression of DCLK3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DCLK3 85443 232399_at 0.0052 0.9845
GSE26886 DCLK3 85443 232399_at 0.1379 0.1155
GSE45670 DCLK3 85443 232399_at 0.0518 0.5256
GSE53622 DCLK3 85443 71890 -0.0619 0.4304
GSE53624 DCLK3 85443 71890 0.4046 0.0000
GSE63941 DCLK3 85443 232399_at 0.0302 0.8168
GSE77861 DCLK3 85443 232399_at -0.0188 0.8544
SRP133303 DCLK3 85443 RNAseq 0.7470 0.0019
SRP159526 DCLK3 85443 RNAseq 2.3826 0.0010
TCGA DCLK3 85443 RNAseq 1.4442 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by DCLK3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DCLK3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DCLK3 85443 0 18 12
GSE20123 DCLK3 85443 0 18 12
GSE43470 DCLK3 85443 0 20 23
GSE46452 DCLK3 85443 2 17 40
GSE47630 DCLK3 85443 1 25 14
GSE54993 DCLK3 85443 6 3 61
GSE54994 DCLK3 85443 1 32 20
GSE60625 DCLK3 85443 5 0 6
GSE74703 DCLK3 85443 0 16 20
GSE74704 DCLK3 85443 0 12 8
TCGA DCLK3 85443 0 71 25

Total number of gains: 15; Total number of losses: 232; Total Number of normals: 241.  

 

Somatic mutations of DCLK3:

 

Generating mutation plots.

 

Highly correlated genes for DCLK3:

 

Showing all 10 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DCLK3NES0.707748303
DCLK3GPR260.664757303
DCLK3VEPH10.606143303
DCLK3PPP2R5B0.586299303
DCLK3CPNE60.583553303
DCLK3CCDC28B0.580643303
DCLK3PNMT0.579139303
DCLK3NACAD0.572351303
DCLK3PDE3A0.557685303
DCLK3SIK10.546059303

For details and further investigation, click here