| Full name: salt inducible kinase 1 | Alias Symbol: msk | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 150094 | HGNC ID: HGNC:11142 | Ensembl Gene: ENSG00000142178 | OMIM ID: 605705 |
| Drug and gene relationship at DGIdb | |||
SIK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04922 | Glucagon signaling pathway |
Expression of SIK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIK1 | 150094 | 232470_at | -0.1187 | 0.7673 | |
| GSE26886 | SIK1 | 150094 | 232470_at | 0.1021 | 0.4647 | |
| GSE45670 | SIK1 | 150094 | 232470_at | 0.0235 | 0.8497 | |
| GSE63941 | SIK1 | 150094 | 232470_at | 0.3075 | 0.0090 | |
| GSE77861 | SIK1 | 150094 | 232470_at | -0.0483 | 0.7998 | |
| GSE97050 | SIK1 | 150094 | A_23_P132121 | 0.1341 | 0.6903 | |
| SRP133303 | SIK1 | 150094 | RNAseq | -0.3006 | 0.4092 | |
| SRP159526 | SIK1 | 150094 | RNAseq | 0.4841 | 0.6390 | |
| TCGA | SIK1 | 150094 | RNAseq | -0.0853 | 0.3048 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIK1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SIK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIK1 | 150094 | 2 | 8 | 20 | |
| GSE20123 | SIK1 | 150094 | 2 | 8 | 20 | |
| GSE43470 | SIK1 | 150094 | 0 | 13 | 30 | |
| GSE46452 | SIK1 | 150094 | 1 | 21 | 37 | |
| GSE47630 | SIK1 | 150094 | 6 | 17 | 17 | |
| GSE54993 | SIK1 | 150094 | 8 | 1 | 61 | |
| GSE54994 | SIK1 | 150094 | 4 | 8 | 41 | |
| GSE60625 | SIK1 | 150094 | 0 | 0 | 11 | |
| GSE74703 | SIK1 | 150094 | 0 | 10 | 26 | |
| GSE74704 | SIK1 | 150094 | 1 | 4 | 15 | |
| TCGA | SIK1 | 150094 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of SIK1:
Generating mutation plots.
Highly correlated genes for SIK1:
Showing top 20/357 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIK1 | MAPRE3 | 0.785364 | 5 | 0 | 5 |
| SIK1 | NDUFA8 | 0.757252 | 3 | 0 | 3 |
| SIK1 | CISD3 | 0.750532 | 3 | 0 | 3 |
| SIK1 | SIN3A | 0.73969 | 3 | 0 | 3 |
| SIK1 | ZNF408 | 0.735121 | 3 | 0 | 3 |
| SIK1 | HES4 | 0.734518 | 3 | 0 | 3 |
| SIK1 | PTP4A3 | 0.733944 | 4 | 0 | 3 |
| SIK1 | LIN37 | 0.723911 | 3 | 0 | 3 |
| SIK1 | PPP2R1A | 0.723608 | 3 | 0 | 3 |
| SIK1 | UNK | 0.722994 | 3 | 0 | 3 |
| SIK1 | ENTPD2 | 0.71772 | 3 | 0 | 3 |
| SIK1 | EMD | 0.717378 | 4 | 0 | 3 |
| SIK1 | COPE | 0.717368 | 3 | 0 | 3 |
| SIK1 | NR1H2 | 0.716633 | 3 | 0 | 3 |
| SIK1 | PHYHIPL | 0.711284 | 3 | 0 | 3 |
| SIK1 | NFKB2 | 0.709321 | 3 | 0 | 3 |
| SIK1 | CDRT15L2 | 0.704104 | 5 | 0 | 5 |
| SIK1 | KLF16 | 0.703301 | 6 | 0 | 6 |
| SIK1 | ADAMTS10 | 0.700784 | 5 | 0 | 5 |
| SIK1 | SLC22A6 | 0.699216 | 3 | 0 | 3 |
For details and further investigation, click here
