| Full name: nestin | Alias Symbol: FLJ21841 | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 10763 | HGNC ID: HGNC:7756 | Ensembl Gene: ENSG00000132688 | OMIM ID: 600915 |
| Drug and gene relationship at DGIdb | |||
Expression of NES:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NES | 10763 | 218678_at | 0.2605 | 0.6528 | |
| GSE20347 | NES | 10763 | 218678_at | 0.3133 | 0.0183 | |
| GSE23400 | NES | 10763 | 218678_at | -0.0233 | 0.7613 | |
| GSE26886 | NES | 10763 | 229346_at | 0.6760 | 0.0028 | |
| GSE29001 | NES | 10763 | 218678_at | 0.3597 | 0.2995 | |
| GSE38129 | NES | 10763 | 218678_at | 0.0953 | 0.8361 | |
| GSE45670 | NES | 10763 | 218678_at | -0.3057 | 0.4187 | |
| GSE53622 | NES | 10763 | 138042 | -0.0557 | 0.7255 | |
| GSE53624 | NES | 10763 | 138042 | 0.2031 | 0.1653 | |
| GSE63941 | NES | 10763 | 218678_at | -0.1886 | 0.8693 | |
| GSE77861 | NES | 10763 | 229346_at | -0.1752 | 0.3282 | |
| GSE97050 | NES | 10763 | A_23_P103672 | -0.1532 | 0.5805 | |
| SRP007169 | NES | 10763 | RNAseq | 1.8822 | 0.0115 | |
| SRP064894 | NES | 10763 | RNAseq | 0.7285 | 0.0321 | |
| SRP133303 | NES | 10763 | RNAseq | 0.3009 | 0.3702 | |
| SRP193095 | NES | 10763 | RNAseq | 1.9777 | 0.0000 | |
| SRP219564 | NES | 10763 | RNAseq | -0.6944 | 0.3410 | |
| TCGA | NES | 10763 | RNAseq | -0.0875 | 0.4404 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NES expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NES:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NES | 10763 | 12 | 0 | 18 | |
| GSE20123 | NES | 10763 | 12 | 0 | 18 | |
| GSE43470 | NES | 10763 | 7 | 2 | 34 | |
| GSE46452 | NES | 10763 | 2 | 1 | 56 | |
| GSE47630 | NES | 10763 | 14 | 0 | 26 | |
| GSE54993 | NES | 10763 | 0 | 5 | 65 | |
| GSE54994 | NES | 10763 | 16 | 0 | 37 | |
| GSE60625 | NES | 10763 | 0 | 0 | 11 | |
| GSE74703 | NES | 10763 | 7 | 2 | 27 | |
| GSE74704 | NES | 10763 | 6 | 0 | 14 | |
| TCGA | NES | 10763 | 38 | 2 | 56 |
Total number of gains: 114; Total number of losses: 12; Total Number of normals: 362.
Somatic mutations of NES:
Generating mutation plots.
Highly correlated genes for NES:
Showing top 20/511 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NES | SNCA | 0.801998 | 3 | 0 | 3 |
| NES | MAP1S | 0.789284 | 3 | 0 | 3 |
| NES | DUSP19 | 0.766152 | 3 | 0 | 3 |
| NES | SARDH | 0.75875 | 3 | 0 | 3 |
| NES | TNP2 | 0.739399 | 3 | 0 | 3 |
| NES | ZNF609 | 0.737267 | 3 | 0 | 3 |
| NES | KCND3 | 0.733252 | 3 | 0 | 3 |
| NES | SYNC | 0.728337 | 3 | 0 | 3 |
| NES | SLC12A4 | 0.727851 | 5 | 0 | 5 |
| NES | ABCB7 | 0.726061 | 3 | 0 | 3 |
| NES | CISD3 | 0.725115 | 3 | 0 | 3 |
| NES | FAM167B | 0.72339 | 3 | 0 | 3 |
| NES | MAPK11 | 0.720907 | 3 | 0 | 3 |
| NES | PEG10 | 0.720226 | 3 | 0 | 3 |
| NES | WIPF3 | 0.709636 | 3 | 0 | 3 |
| NES | DCLK3 | 0.707748 | 3 | 0 | 3 |
| NES | NMNAT2 | 0.705435 | 4 | 0 | 3 |
| NES | ZNF771 | 0.704084 | 3 | 0 | 3 |
| NES | B4GALNT4 | 0.703504 | 4 | 0 | 3 |
| NES | PKN3 | 0.702128 | 3 | 0 | 3 |
For details and further investigation, click here
