| Full name: Down syndrome critical region 8 | Alias Symbol: MTAG2|CT25.1a|CT25.1b|MMA-1a|MMA-1b | ||
| Type: non-coding RNA | Cytoband: 21q22.13 | ||
| Entrez ID: 84677 | HGNC ID: HGNC:16707 | Ensembl Gene: ENSG00000198054 | OMIM ID: 613396 |
| Drug and gene relationship at DGIdb | |||
Expression of DSCR8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSCR8 | 84677 | 241224_x_at | 0.3258 | 0.6173 | |
| GSE26886 | DSCR8 | 84677 | 241224_x_at | -0.1925 | 0.0694 | |
| GSE45670 | DSCR8 | 84677 | 241224_x_at | 0.2740 | 0.4051 | |
| GSE53622 | DSCR8 | 84677 | 68761 | 1.1831 | 0.0046 | |
| GSE53624 | DSCR8 | 84677 | 68761 | 1.2016 | 0.0000 | |
| GSE63941 | DSCR8 | 84677 | 241224_x_at | -0.0079 | 0.9950 | |
| GSE77861 | DSCR8 | 84677 | 241224_x_at | -0.0901 | 0.3441 | |
| TCGA | DSCR8 | 84677 | RNAseq | 3.4519 | 0.1776 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DSCR8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSCR8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSCR8 | 84677 | 2 | 9 | 19 | |
| GSE20123 | DSCR8 | 84677 | 2 | 10 | 18 | |
| GSE43470 | DSCR8 | 84677 | 1 | 11 | 31 | |
| GSE46452 | DSCR8 | 84677 | 1 | 21 | 37 | |
| GSE47630 | DSCR8 | 84677 | 6 | 17 | 17 | |
| GSE54993 | DSCR8 | 84677 | 8 | 1 | 61 | |
| GSE54994 | DSCR8 | 84677 | 3 | 9 | 41 | |
| GSE60625 | DSCR8 | 84677 | 0 | 0 | 11 | |
| GSE74703 | DSCR8 | 84677 | 1 | 8 | 27 | |
| GSE74704 | DSCR8 | 84677 | 1 | 7 | 12 | |
| TCGA | DSCR8 | 84677 | 8 | 41 | 47 |
Total number of gains: 33; Total number of losses: 134; Total Number of normals: 321.
Somatic mutations of DSCR8:
Generating mutation plots.
Highly correlated genes for DSCR8:
Showing all 17 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSCR8 | WNK2 | 0.697724 | 3 | 0 | 3 |
| DSCR8 | LINC01410 | 0.643778 | 3 | 0 | 3 |
| DSCR8 | VGLL1 | 0.639709 | 3 | 0 | 3 |
| DSCR8 | TCP11 | 0.62965 | 3 | 0 | 3 |
| DSCR8 | LINC01197 | 0.617925 | 3 | 0 | 3 |
| DSCR8 | TNNT3 | 0.610474 | 3 | 0 | 3 |
| DSCR8 | LGALS14 | 0.608425 | 3 | 0 | 3 |
| DSCR8 | LY6G5C | 0.607981 | 4 | 0 | 3 |
| DSCR8 | KRTAP19-3 | 0.601587 | 3 | 0 | 3 |
| DSCR8 | GYPB | 0.600398 | 3 | 0 | 3 |
| DSCR8 | RHOH | 0.599769 | 4 | 0 | 3 |
| DSCR8 | ZDHHC19 | 0.586977 | 3 | 0 | 3 |
| DSCR8 | SUN5 | 0.571112 | 3 | 0 | 3 |
| DSCR8 | NRSN1 | 0.566907 | 3 | 0 | 3 |
| DSCR8 | LINC00879 | 0.518873 | 3 | 0 | 3 |
| DSCR8 | DEFB127 | 0.511154 | 4 | 0 | 3 |
| DSCR8 | LDHAL6A | 0.505483 | 4 | 0 | 3 |
For details and further investigation, click here
