| Full name: troponin T3, fast skeletal type | Alias Symbol: AMCD2B|DA2B|FSSV|DKFZp779M2348 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 7140 | HGNC ID: HGNC:11950 | Ensembl Gene: ENSG00000130595 | OMIM ID: 600692 |
| Drug and gene relationship at DGIdb | |||
Expression of TNNT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNNT3 | 7140 | 1569986_x_at | -0.1911 | 0.5949 | |
| GSE20347 | TNNT3 | 7140 | 205693_at | -0.1420 | 0.0910 | |
| GSE23400 | TNNT3 | 7140 | 205693_at | -0.1318 | 0.0092 | |
| GSE26886 | TNNT3 | 7140 | 1569986_x_at | -0.2307 | 0.0986 | |
| GSE29001 | TNNT3 | 7140 | 205693_at | 0.1428 | 0.5671 | |
| GSE38129 | TNNT3 | 7140 | 205693_at | -0.2311 | 0.0043 | |
| GSE45670 | TNNT3 | 7140 | 1569986_x_at | -0.1404 | 0.0507 | |
| GSE53622 | TNNT3 | 7140 | 9588 | 0.3999 | 0.0048 | |
| GSE53624 | TNNT3 | 7140 | 9588 | 0.2443 | 0.0401 | |
| GSE63941 | TNNT3 | 7140 | 1569986_x_at | 0.5581 | 0.0137 | |
| GSE77861 | TNNT3 | 7140 | 1569986_x_at | -0.0533 | 0.6120 | |
| GSE97050 | TNNT3 | 7140 | A_23_P127824 | -0.3499 | 0.4213 | |
| SRP064894 | TNNT3 | 7140 | RNAseq | -0.6041 | 0.2671 | |
| SRP133303 | TNNT3 | 7140 | RNAseq | -1.1311 | 0.0577 | |
| SRP159526 | TNNT3 | 7140 | RNAseq | -0.5266 | 0.5159 | |
| SRP219564 | TNNT3 | 7140 | RNAseq | 1.0676 | 0.2256 | |
| TCGA | TNNT3 | 7140 | RNAseq | -0.1823 | 0.7722 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TNNT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNNT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNNT3 | 7140 | 1 | 11 | 18 | |
| GSE20123 | TNNT3 | 7140 | 1 | 12 | 17 | |
| GSE43470 | TNNT3 | 7140 | 1 | 9 | 33 | |
| GSE46452 | TNNT3 | 7140 | 7 | 8 | 44 | |
| GSE47630 | TNNT3 | 7140 | 4 | 12 | 24 | |
| GSE54993 | TNNT3 | 7140 | 3 | 1 | 66 | |
| GSE54994 | TNNT3 | 7140 | 1 | 12 | 40 | |
| GSE60625 | TNNT3 | 7140 | 0 | 0 | 11 | |
| GSE74703 | TNNT3 | 7140 | 1 | 7 | 28 | |
| GSE74704 | TNNT3 | 7140 | 0 | 8 | 12 | |
| TCGA | TNNT3 | 7140 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 119; Total Number of normals: 342.
Somatic mutations of TNNT3:
Generating mutation plots.
Highly correlated genes for TNNT3:
Showing top 20/352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNNT3 | WNK2 | 0.688695 | 4 | 0 | 3 |
| TNNT3 | LGALS12 | 0.68346 | 3 | 0 | 3 |
| TNNT3 | PLA2G2C | 0.67514 | 3 | 0 | 3 |
| TNNT3 | TMEM229A | 0.675123 | 3 | 0 | 3 |
| TNNT3 | GJD4 | 0.673595 | 4 | 0 | 4 |
| TNNT3 | ABCD3 | 0.673576 | 3 | 0 | 3 |
| TNNT3 | OR2A5 | 0.672495 | 3 | 0 | 3 |
| TNNT3 | DCDC1 | 0.672421 | 3 | 0 | 3 |
| TNNT3 | KRTAP5-AS1 | 0.669563 | 3 | 0 | 3 |
| TNNT3 | GRIK4 | 0.666226 | 3 | 0 | 3 |
| TNNT3 | STRC | 0.664534 | 3 | 0 | 3 |
| TNNT3 | SLC39A5 | 0.662751 | 3 | 0 | 3 |
| TNNT3 | OPTC | 0.66273 | 5 | 0 | 5 |
| TNNT3 | KRTAP10-12 | 0.66226 | 3 | 0 | 3 |
| TNNT3 | TMEM221 | 0.658335 | 3 | 0 | 3 |
| TNNT3 | CLDN8 | 0.656985 | 3 | 0 | 3 |
| TNNT3 | SPRYD3 | 0.656546 | 3 | 0 | 3 |
| TNNT3 | CLCNKA | 0.656484 | 3 | 0 | 3 |
| TNNT3 | BBC3 | 0.65283 | 3 | 0 | 3 |
| TNNT3 | ABI3 | 0.651176 | 3 | 0 | 3 |
For details and further investigation, click here
