FLG2

 

Full name: filaggrin family member 2 Alias Symbol: IFPS
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 388698 HGNC ID: HGNC:33276 Ensembl Gene: ENSG00000143520 OMIM ID: 616284
Drug and gene relationship at DGIdb

 

Expression of FLG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FLG2 388698 1569410_at 0.2539 0.7140
GSE26886 FLG2 388698 1569410_at -0.7494 0.0018
GSE45670 FLG2 388698 1569410_at 0.4765 0.4146
GSE53622 FLG2 388698 22631 -0.7800 0.0013
GSE53624 FLG2 388698 22631 -0.7680 0.0091
GSE63941 FLG2 388698 1569410_at -0.0541 0.7202
GSE77861 FLG2 388698 1569410_at 0.0315 0.8856
SRP007169 FLG2 388698 RNAseq -1.0970 0.2295
SRP064894 FLG2 388698 RNAseq -1.8266 0.0010
SRP133303 FLG2 388698 RNAseq -1.9598 0.0000
TCGA FLG2 388698 RNAseq 0.2102 0.7444

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by FLG2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FLG2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FLG2 388698 14 0 16
GSE20123 FLG2 388698 14 0 16
GSE43470 FLG2 388698 6 2 35
GSE46452 FLG2 388698 2 1 56
GSE47630 FLG2 388698 15 0 25
GSE54993 FLG2 388698 0 4 66
GSE54994 FLG2 388698 15 1 37
GSE60625 FLG2 388698 0 0 11
GSE74703 FLG2 388698 6 1 29
GSE74704 FLG2 388698 7 0 13
TCGA FLG2 388698 39 2 55

Total number of gains: 118; Total number of losses: 11; Total Number of normals: 359.  

 

Somatic mutations of FLG2:

 

Generating mutation plots.

 

Highly correlated genes for FLG2:

 

Showing all 9 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FLG2LOR0.603319605
FLG2RDH120.579046404
FLG2ARG10.571739504
FLG2FAM160A10.570308404
FLG2RPTN0.569797403
FLG2CARD180.55745503
FLG2PSG60.537276303
FLG2SERPINB120.522854503
FLG2CSNK1A10.518907403

For details and further investigation, click here