| Full name: arginase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q23.2 | ||
| Entrez ID: 383 | HGNC ID: HGNC:663 | Ensembl Gene: ENSG00000118520 | OMIM ID: 608313 |
| Drug and gene relationship at DGIdb | |||
Expression of ARG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARG1 | 383 | 206177_s_at | -0.2542 | 0.8525 | |
| GSE20347 | ARG1 | 383 | 206177_s_at | -0.9252 | 0.0161 | |
| GSE23400 | ARG1 | 383 | 206177_s_at | -0.2693 | 0.0000 | |
| GSE26886 | ARG1 | 383 | 206177_s_at | -1.8877 | 0.0002 | |
| GSE29001 | ARG1 | 383 | 206177_s_at | -1.6932 | 0.0086 | |
| GSE38129 | ARG1 | 383 | 206177_s_at | -1.0172 | 0.0038 | |
| GSE45670 | ARG1 | 383 | 206177_s_at | -1.3024 | 0.0403 | |
| GSE53622 | ARG1 | 383 | 6449 | -1.2322 | 0.0000 | |
| GSE53624 | ARG1 | 383 | 6449 | -2.1032 | 0.0000 | |
| GSE63941 | ARG1 | 383 | 231663_s_at | 0.1981 | 0.0709 | |
| GSE77861 | ARG1 | 383 | 206177_s_at | -0.9827 | 0.0417 | |
| GSE97050 | ARG1 | 383 | A_33_P3352382 | 0.5217 | 0.4825 | |
| SRP007169 | ARG1 | 383 | RNAseq | -5.4737 | 0.0000 | |
| SRP064894 | ARG1 | 383 | RNAseq | -2.1463 | 0.0000 | |
| SRP133303 | ARG1 | 383 | RNAseq | -1.9341 | 0.0000 | |
| SRP193095 | ARG1 | 383 | RNAseq | -2.5050 | 0.0000 | |
| TCGA | ARG1 | 383 | RNAseq | 0.3945 | 0.6135 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by ARG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARG1 | 383 | 2 | 5 | 23 | |
| GSE20123 | ARG1 | 383 | 2 | 4 | 24 | |
| GSE43470 | ARG1 | 383 | 5 | 0 | 38 | |
| GSE46452 | ARG1 | 383 | 2 | 11 | 46 | |
| GSE47630 | ARG1 | 383 | 9 | 4 | 27 | |
| GSE54993 | ARG1 | 383 | 3 | 2 | 65 | |
| GSE54994 | ARG1 | 383 | 9 | 7 | 37 | |
| GSE60625 | ARG1 | 383 | 0 | 1 | 10 | |
| GSE74703 | ARG1 | 383 | 4 | 0 | 32 | |
| GSE74704 | ARG1 | 383 | 1 | 1 | 18 | |
| TCGA | ARG1 | 383 | 11 | 18 | 67 |
Total number of gains: 48; Total number of losses: 53; Total Number of normals: 387.
Somatic mutations of ARG1:
Generating mutation plots.
Highly correlated genes for ARG1:
Showing top 20/424 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARG1 | TREX2 | 0.680848 | 3 | 0 | 3 |
| ARG1 | FOXN4 | 0.643074 | 3 | 0 | 3 |
| ARG1 | ATG9B | 0.638611 | 7 | 0 | 6 |
| ARG1 | DENND2C | 0.638054 | 5 | 0 | 5 |
| ARG1 | STXBP5 | 0.637776 | 4 | 0 | 4 |
| ARG1 | YOD1 | 0.63494 | 9 | 0 | 7 |
| ARG1 | ENDOU | 0.633193 | 10 | 0 | 9 |
| ARG1 | GPLD1 | 0.632025 | 3 | 0 | 3 |
| ARG1 | SESN2 | 0.630521 | 5 | 0 | 5 |
| ARG1 | TYRO3 | 0.629068 | 10 | 0 | 9 |
| ARG1 | MXD1 | 0.625306 | 9 | 0 | 8 |
| ARG1 | GYS2 | 0.625025 | 10 | 0 | 9 |
| ARG1 | C7orf57 | 0.62313 | 6 | 0 | 5 |
| ARG1 | RDH12 | 0.62094 | 8 | 0 | 6 |
| ARG1 | ALOX12 | 0.619999 | 10 | 0 | 10 |
| ARG1 | SH3BGRL2 | 0.617975 | 5 | 0 | 4 |
| ARG1 | FLG | 0.615524 | 11 | 0 | 9 |
| ARG1 | ACER1 | 0.615006 | 6 | 0 | 5 |
| ARG1 | CACNG6 | 0.613953 | 4 | 0 | 4 |
| ARG1 | RNASE7 | 0.610787 | 6 | 0 | 5 |
For details and further investigation, click here
