| Full name: serpin family B member 12 | Alias Symbol: YUKOPIN | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 89777 | HGNC ID: HGNC:14220 | Ensembl Gene: ENSG00000166634 | OMIM ID: 615662 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINB12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB12 | 89777 | 1553057_at | -0.3175 | 0.6112 | |
| GSE26886 | SERPINB12 | 89777 | 1553057_at | -0.2642 | 0.0168 | |
| GSE45670 | SERPINB12 | 89777 | 1553057_at | -0.2058 | 0.0931 | |
| GSE53622 | SERPINB12 | 89777 | 58178 | -2.5990 | 0.0000 | |
| GSE53624 | SERPINB12 | 89777 | 58178 | -3.8774 | 0.0000 | |
| GSE63941 | SERPINB12 | 89777 | 1553057_at | 0.1549 | 0.2974 | |
| GSE77861 | SERPINB12 | 89777 | 1553057_at | -0.1191 | 0.6104 | |
| SRP007169 | SERPINB12 | 89777 | RNAseq | -5.5463 | 0.0000 | |
| SRP008496 | SERPINB12 | 89777 | RNAseq | -3.3425 | 0.0066 | |
| SRP064894 | SERPINB12 | 89777 | RNAseq | -3.3992 | 0.0000 | |
| SRP133303 | SERPINB12 | 89777 | RNAseq | -2.3586 | 0.0000 | |
| SRP159526 | SERPINB12 | 89777 | RNAseq | -2.1292 | 0.0257 | |
| SRP193095 | SERPINB12 | 89777 | RNAseq | -1.1374 | 0.0083 | |
| SRP219564 | SERPINB12 | 89777 | RNAseq | -3.5991 | 0.0004 | |
| TCGA | SERPINB12 | 89777 | RNAseq | 0.5426 | 0.5532 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by SERPINB12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB12 | 89777 | 1 | 9 | 20 | |
| GSE20123 | SERPINB12 | 89777 | 1 | 9 | 20 | |
| GSE43470 | SERPINB12 | 89777 | 0 | 7 | 36 | |
| GSE46452 | SERPINB12 | 89777 | 1 | 26 | 32 | |
| GSE47630 | SERPINB12 | 89777 | 5 | 21 | 14 | |
| GSE54993 | SERPINB12 | 89777 | 9 | 0 | 61 | |
| GSE54994 | SERPINB12 | 89777 | 1 | 18 | 34 | |
| GSE60625 | SERPINB12 | 89777 | 0 | 4 | 7 | |
| GSE74703 | SERPINB12 | 89777 | 0 | 7 | 29 | |
| GSE74704 | SERPINB12 | 89777 | 1 | 6 | 13 | |
| TCGA | SERPINB12 | 89777 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of SERPINB12:
Generating mutation plots.
Highly correlated genes for SERPINB12:
Showing top 20/665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB12 | CRISP2 | 0.7308 | 3 | 0 | 3 |
| SERPINB12 | CEACAM3 | 0.712283 | 3 | 0 | 3 |
| SERPINB12 | TMPRSS11E | 0.700867 | 6 | 0 | 6 |
| SERPINB12 | IQCF1 | 0.699011 | 4 | 0 | 4 |
| SERPINB12 | LAMB4 | 0.697935 | 3 | 0 | 3 |
| SERPINB12 | LGI3 | 0.69331 | 3 | 0 | 3 |
| SERPINB12 | TFAP2B | 0.692005 | 3 | 0 | 3 |
| SERPINB12 | MORN3 | 0.683211 | 3 | 0 | 3 |
| SERPINB12 | PLEKHM1 | 0.682998 | 6 | 0 | 5 |
| SERPINB12 | CEACAM6 | 0.682008 | 5 | 0 | 5 |
| SERPINB12 | PRSS27 | 0.681607 | 5 | 0 | 5 |
| SERPINB12 | TAX1BP1 | 0.681496 | 3 | 0 | 3 |
| SERPINB12 | YOD1 | 0.680825 | 4 | 0 | 3 |
| SERPINB12 | FLG-AS1 | 0.678763 | 5 | 0 | 5 |
| SERPINB12 | EPS8L1 | 0.678613 | 5 | 0 | 5 |
| SERPINB12 | SMIM5 | 0.678539 | 6 | 0 | 5 |
| SERPINB12 | PTPN13 | 0.678184 | 3 | 0 | 3 |
| SERPINB12 | PLEKHN1 | 0.676909 | 4 | 0 | 4 |
| SERPINB12 | LINC00320 | 0.675146 | 3 | 0 | 3 |
| SERPINB12 | RAD21L1 | 0.674979 | 3 | 0 | 3 |
For details and further investigation, click here
