| Full name: casein kinase 1 alpha 1 | Alias Symbol: CK1|CK1a|CK1alpha|CKIa|CKIalpha | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 1452 | HGNC ID: HGNC:2451 | Ensembl Gene: ENSG00000113712 | OMIM ID: 600505 |
| Related drugs: CHEMBL410456, HEPARIN, IC261... [more] | |||
Screen Evidence:
| |||
CSNK1A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway | |
| hsa04340 | Hedgehog signaling pathway |
Expression of CSNK1A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSNK1A1 | 1452 | 208865_at | -0.3097 | 0.3817 | |
| GSE20347 | CSNK1A1 | 1452 | 208865_at | -0.5818 | 0.0000 | |
| GSE23400 | CSNK1A1 | 1452 | 208865_at | -0.2038 | 0.0016 | |
| GSE26886 | CSNK1A1 | 1452 | 208865_at | -1.0526 | 0.0000 | |
| GSE29001 | CSNK1A1 | 1452 | 208865_at | -0.1895 | 0.2394 | |
| GSE38129 | CSNK1A1 | 1452 | 208865_at | -0.3950 | 0.0032 | |
| GSE45670 | CSNK1A1 | 1452 | 208865_at | 0.0943 | 0.5055 | |
| GSE53622 | CSNK1A1 | 1452 | 42094 | -0.5022 | 0.0000 | |
| GSE53624 | CSNK1A1 | 1452 | 42094 | -0.3070 | 0.0000 | |
| GSE63941 | CSNK1A1 | 1452 | 213860_x_at | 0.6098 | 0.1227 | |
| GSE77861 | CSNK1A1 | 1452 | 208865_at | -0.1819 | 0.4059 | |
| GSE97050 | CSNK1A1 | 1452 | A_24_P183292 | -0.0619 | 0.8395 | |
| SRP007169 | CSNK1A1 | 1452 | RNAseq | -1.2795 | 0.0000 | |
| SRP008496 | CSNK1A1 | 1452 | RNAseq | -1.1906 | 0.0000 | |
| SRP064894 | CSNK1A1 | 1452 | RNAseq | -0.3636 | 0.0092 | |
| SRP133303 | CSNK1A1 | 1452 | RNAseq | 0.0236 | 0.8510 | |
| SRP159526 | CSNK1A1 | 1452 | RNAseq | -0.4959 | 0.2078 | |
| SRP193095 | CSNK1A1 | 1452 | RNAseq | -0.3341 | 0.0177 | |
| SRP219564 | CSNK1A1 | 1452 | RNAseq | -0.5062 | 0.1851 | |
| TCGA | CSNK1A1 | 1452 | RNAseq | 0.0270 | 0.5347 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CSNK1A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSNK1A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSNK1A1 | 1452 | 1 | 12 | 17 | |
| GSE20123 | CSNK1A1 | 1452 | 1 | 12 | 17 | |
| GSE43470 | CSNK1A1 | 1452 | 1 | 10 | 32 | |
| GSE46452 | CSNK1A1 | 1452 | 0 | 27 | 32 | |
| GSE47630 | CSNK1A1 | 1452 | 0 | 20 | 20 | |
| GSE54993 | CSNK1A1 | 1452 | 9 | 1 | 60 | |
| GSE54994 | CSNK1A1 | 1452 | 2 | 15 | 36 | |
| GSE60625 | CSNK1A1 | 1452 | 0 | 0 | 11 | |
| GSE74703 | CSNK1A1 | 1452 | 1 | 7 | 28 | |
| GSE74704 | CSNK1A1 | 1452 | 1 | 7 | 12 | |
| TCGA | CSNK1A1 | 1452 | 5 | 39 | 52 |
Total number of gains: 21; Total number of losses: 150; Total Number of normals: 317.
Somatic mutations of CSNK1A1:
Generating mutation plots.
Highly correlated genes for CSNK1A1:
Showing top 20/1054 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSNK1A1 | MLKL | 0.827489 | 3 | 0 | 3 |
| CSNK1A1 | SCYL2 | 0.794668 | 3 | 0 | 3 |
| CSNK1A1 | TBC1D23 | 0.758251 | 4 | 0 | 4 |
| CSNK1A1 | FYTTD1 | 0.747142 | 4 | 0 | 4 |
| CSNK1A1 | ABHD4 | 0.743835 | 3 | 0 | 3 |
| CSNK1A1 | ALDH2 | 0.743149 | 4 | 0 | 4 |
| CSNK1A1 | NBR1 | 0.736047 | 3 | 0 | 3 |
| CSNK1A1 | SRGAP2 | 0.734752 | 3 | 0 | 3 |
| CSNK1A1 | CCDC25 | 0.734225 | 3 | 0 | 3 |
| CSNK1A1 | RNF149 | 0.730782 | 3 | 0 | 3 |
| CSNK1A1 | OSBPL8 | 0.726826 | 4 | 0 | 3 |
| CSNK1A1 | FNIP1 | 0.726103 | 4 | 0 | 4 |
| CSNK1A1 | IBTK | 0.725179 | 6 | 0 | 6 |
| CSNK1A1 | PCM1 | 0.720405 | 3 | 0 | 3 |
| CSNK1A1 | GRPEL2 | 0.716839 | 6 | 0 | 6 |
| CSNK1A1 | PTPN23 | 0.716321 | 3 | 0 | 3 |
| CSNK1A1 | SLU7 | 0.714935 | 5 | 0 | 4 |
| CSNK1A1 | FAM174A | 0.713916 | 8 | 0 | 7 |
| CSNK1A1 | PFKFB2 | 0.711055 | 5 | 0 | 5 |
| CSNK1A1 | RNGTT | 0.708933 | 4 | 0 | 3 |
For details and further investigation, click here
