GNAO1

 

Full name: G protein subunit alpha o1 Alias Symbol: G-ALPHA-o
Type: protein-coding gene Cytoband: 16q13
Entrez ID: 2775 HGNC ID: HGNC:4389 Ensembl Gene: ENSG00000087258 OMIM ID: 139311
Drug and gene relationship at DGIdb

 

GNAO1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis

 

Expression of GNAO1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNAO1 2775 231951_at 0.2756 0.3905
GSE20347 GNAO1 2775 204763_s_at 0.0502 0.6405
GSE23400 GNAO1 2775 204763_s_at -0.1513 0.0010
GSE26886 GNAO1 2775 231951_at 0.0259 0.9432
GSE29001 GNAO1 2775 204763_s_at -0.1150 0.7079
GSE38129 GNAO1 2775 204763_s_at -0.2798 0.0241
GSE45670 GNAO1 2775 231951_at -0.0629 0.5970
GSE53622 GNAO1 2775 78541 -0.8608 0.0000
GSE53624 GNAO1 2775 78541 -0.3945 0.0000
GSE63941 GNAO1 2775 231951_at 1.0542 0.0009
GSE77861 GNAO1 2775 231951_at 0.0738 0.7274
GSE97050 GNAO1 2775 A_24_P393611 -0.3937 0.3516
SRP064894 GNAO1 2775 RNAseq -0.8687 0.0027
SRP133303 GNAO1 2775 RNAseq -1.0438 0.0002
SRP159526 GNAO1 2775 RNAseq -1.2266 0.0028
SRP193095 GNAO1 2775 RNAseq -0.2220 0.3312
SRP219564 GNAO1 2775 RNAseq 0.2606 0.7384
TCGA GNAO1 2775 RNAseq -0.7561 0.0000

Upregulated datasets: 1; Downregulated datasets: 2.  

 

Survival by GNAO1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNAO1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNAO1 2775 4 0 26
GSE20123 GNAO1 2775 4 0 26
GSE43470 GNAO1 2775 2 7 34
GSE46452 GNAO1 2775 38 1 20
GSE47630 GNAO1 2775 10 8 22
GSE54993 GNAO1 2775 2 4 64
GSE54994 GNAO1 2775 7 10 36
GSE60625 GNAO1 2775 4 0 7
GSE74703 GNAO1 2775 2 4 30
GSE74704 GNAO1 2775 3 0 17
TCGA GNAO1 2775 25 12 59

Total number of gains: 101; Total number of losses: 46; Total Number of normals: 341.  

 

Somatic mutations of GNAO1:

 

Generating mutation plots.

 

Highly correlated genes for GNAO1:

 

Showing top 20/595 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNAO1VWA3A0.770954403
GNAO1ZNF5480.755697404
GNAO1SYT150.735364303
GNAO1CHD30.71654303
GNAO1TSACC0.705246403
GNAO1C14orf280.694591303
GNAO1SLC25A350.688485404
GNAO1KRBOX1-AS10.685621303
GNAO1NUCB10.684067404
GNAO1ASB120.683655403
GNAO1HES40.682169303
GNAO1ZFP920.680793403
GNAO1NR1H20.678145303
GNAO1LINC002260.672997303
GNAO1ZMYM30.672442404
GNAO1PPP1R14A0.67189303
GNAO1SPATA240.668944503
GNAO1IL1RAPL20.663986606
GNAO1KIAA07540.662626303
GNAO1KLHL220.662417303

For details and further investigation, click here