| Full name: hes family bHLH transcription factor 4 | Alias Symbol: bHLHb42 | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 57801 | HGNC ID: HGNC:24149 | Ensembl Gene: ENSG00000188290 | OMIM ID: 608060 |
| Drug and gene relationship at DGIdb | |||
Expression of HES4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HES4 | 57801 | 227347_x_at | 0.0768 | 0.8914 | |
| GSE26886 | HES4 | 57801 | 227347_x_at | 1.5503 | 0.0000 | |
| GSE45670 | HES4 | 57801 | 227347_x_at | 0.0781 | 0.7442 | |
| GSE53622 | HES4 | 57801 | 101411 | 0.2216 | 0.0677 | |
| GSE53624 | HES4 | 57801 | 101411 | 0.6693 | 0.0000 | |
| GSE63941 | HES4 | 57801 | 227347_x_at | 3.2137 | 0.0001 | |
| GSE77861 | HES4 | 57801 | 227347_x_at | 0.1412 | 0.2964 | |
| GSE97050 | HES4 | 57801 | A_33_P3342628 | 0.0709 | 0.7751 | |
| SRP007169 | HES4 | 57801 | RNAseq | -1.3941 | 0.0063 | |
| SRP064894 | HES4 | 57801 | RNAseq | 0.5261 | 0.1612 | |
| SRP133303 | HES4 | 57801 | RNAseq | 0.8036 | 0.0106 | |
| SRP159526 | HES4 | 57801 | RNAseq | -0.0558 | 0.8991 | |
| SRP219564 | HES4 | 57801 | RNAseq | 0.4205 | 0.2630 | |
| TCGA | HES4 | 57801 | RNAseq | 0.6029 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by HES4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HES4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HES4 | 57801 | 3 | 7 | 20 | |
| GSE20123 | HES4 | 57801 | 3 | 6 | 21 | |
| GSE43470 | HES4 | 57801 | 1 | 5 | 37 | |
| GSE46452 | HES4 | 57801 | 7 | 1 | 51 | |
| GSE47630 | HES4 | 57801 | 8 | 4 | 28 | |
| GSE54993 | HES4 | 57801 | 2 | 2 | 66 | |
| GSE54994 | HES4 | 57801 | 15 | 2 | 36 | |
| GSE60625 | HES4 | 57801 | 0 | 0 | 11 | |
| GSE74703 | HES4 | 57801 | 1 | 3 | 32 | |
| GSE74704 | HES4 | 57801 | 3 | 0 | 17 | |
| TCGA | HES4 | 57801 | 14 | 20 | 62 |
Total number of gains: 57; Total number of losses: 50; Total Number of normals: 381.
Somatic mutations of HES4:
Generating mutation plots.
Highly correlated genes for HES4:
Showing top 20/491 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HES4 | ATN1 | 0.815498 | 3 | 0 | 3 |
| HES4 | SLC25A42 | 0.807698 | 3 | 0 | 3 |
| HES4 | TTF1 | 0.792765 | 3 | 0 | 3 |
| HES4 | RPA3 | 0.781842 | 3 | 0 | 3 |
| HES4 | ITGB4 | 0.776639 | 4 | 0 | 4 |
| HES4 | LSM4 | 0.776368 | 3 | 0 | 3 |
| HES4 | MAPK9 | 0.769639 | 3 | 0 | 3 |
| HES4 | DUT | 0.7681 | 3 | 0 | 3 |
| HES4 | NUCKS1 | 0.760143 | 3 | 0 | 3 |
| HES4 | HAUS7 | 0.75415 | 3 | 0 | 3 |
| HES4 | MRPL38 | 0.752999 | 3 | 0 | 3 |
| HES4 | MRPL24 | 0.743341 | 3 | 0 | 3 |
| HES4 | HEATR6 | 0.742244 | 3 | 0 | 3 |
| HES4 | COMMD7 | 0.740025 | 3 | 0 | 3 |
| HES4 | TMEM205 | 0.735443 | 3 | 0 | 3 |
| HES4 | SIK1 | 0.734518 | 3 | 0 | 3 |
| HES4 | SLC38A10 | 0.733771 | 3 | 0 | 3 |
| HES4 | COPE | 0.73326 | 3 | 0 | 3 |
| HES4 | RPL24 | 0.731754 | 3 | 0 | 3 |
| HES4 | MFHAS1 | 0.731651 | 3 | 0 | 3 |
For details and further investigation, click here
