| Full name: nucleobindin 1 | Alias Symbol: NUC|Calnuc | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 4924 | HGNC ID: HGNC:8043 | Ensembl Gene: ENSG00000104805 | OMIM ID: 601323 |
| Drug and gene relationship at DGIdb | |||
Expression of NUCB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUCB1 | 4924 | 200649_at | 0.1010 | 0.8635 | |
| GSE20347 | NUCB1 | 4924 | 200649_at | -0.2568 | 0.0311 | |
| GSE23400 | NUCB1 | 4924 | 200649_at | -0.0281 | 0.6612 | |
| GSE26886 | NUCB1 | 4924 | 200649_at | -0.5849 | 0.0277 | |
| GSE29001 | NUCB1 | 4924 | 200649_at | -0.2177 | 0.5911 | |
| GSE38129 | NUCB1 | 4924 | 200649_at | -0.1630 | 0.1398 | |
| GSE45670 | NUCB1 | 4924 | 200649_at | 0.0224 | 0.8510 | |
| GSE53622 | NUCB1 | 4924 | 37438 | -0.2112 | 0.0075 | |
| GSE53624 | NUCB1 | 4924 | 37438 | -0.1460 | 0.0312 | |
| GSE63941 | NUCB1 | 4924 | 200649_at | 1.5061 | 0.0024 | |
| GSE77861 | NUCB1 | 4924 | 200649_at | 0.0254 | 0.9584 | |
| GSE97050 | NUCB1 | 4924 | A_23_P78771 | -0.3805 | 0.2332 | |
| SRP007169 | NUCB1 | 4924 | RNAseq | -1.0245 | 0.0055 | |
| SRP008496 | NUCB1 | 4924 | RNAseq | -0.9753 | 0.0000 | |
| SRP064894 | NUCB1 | 4924 | RNAseq | 0.4308 | 0.1014 | |
| SRP133303 | NUCB1 | 4924 | RNAseq | -0.0849 | 0.6807 | |
| SRP159526 | NUCB1 | 4924 | RNAseq | 0.0486 | 0.8162 | |
| SRP193095 | NUCB1 | 4924 | RNAseq | -0.0967 | 0.5172 | |
| SRP219564 | NUCB1 | 4924 | RNAseq | -0.0773 | 0.8737 | |
| TCGA | NUCB1 | 4924 | RNAseq | -0.1235 | 0.0013 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by NUCB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUCB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUCB1 | 4924 | 4 | 4 | 22 | |
| GSE20123 | NUCB1 | 4924 | 4 | 3 | 23 | |
| GSE43470 | NUCB1 | 4924 | 4 | 10 | 29 | |
| GSE46452 | NUCB1 | 4924 | 45 | 1 | 13 | |
| GSE47630 | NUCB1 | 4924 | 9 | 6 | 25 | |
| GSE54993 | NUCB1 | 4924 | 17 | 4 | 49 | |
| GSE54994 | NUCB1 | 4924 | 4 | 14 | 35 | |
| GSE60625 | NUCB1 | 4924 | 9 | 0 | 2 | |
| GSE74703 | NUCB1 | 4924 | 4 | 7 | 25 | |
| GSE74704 | NUCB1 | 4924 | 4 | 1 | 15 | |
| TCGA | NUCB1 | 4924 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of NUCB1:
Generating mutation plots.
Highly correlated genes for NUCB1:
Showing top 20/429 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUCB1 | WDTC1 | 0.816847 | 3 | 0 | 3 |
| NUCB1 | HDAC11 | 0.781746 | 3 | 0 | 3 |
| NUCB1 | AAAS | 0.761189 | 4 | 0 | 4 |
| NUCB1 | INPP5E | 0.751603 | 3 | 0 | 3 |
| NUCB1 | NPFF | 0.751491 | 3 | 0 | 3 |
| NUCB1 | TRAPPC1 | 0.742659 | 3 | 0 | 3 |
| NUCB1 | PDK2 | 0.738397 | 4 | 0 | 4 |
| NUCB1 | MPV17L | 0.738075 | 3 | 0 | 3 |
| NUCB1 | VRK3 | 0.735294 | 5 | 0 | 5 |
| NUCB1 | MRPL38 | 0.724486 | 4 | 0 | 4 |
| NUCB1 | RPS19 | 0.724027 | 3 | 0 | 3 |
| NUCB1 | MED12 | 0.721383 | 4 | 0 | 4 |
| NUCB1 | BCL9L | 0.718269 | 3 | 0 | 3 |
| NUCB1 | EHMT2 | 0.716647 | 4 | 0 | 4 |
| NUCB1 | ARHGEF16 | 0.715651 | 5 | 0 | 4 |
| NUCB1 | SRSF5 | 0.714235 | 3 | 0 | 3 |
| NUCB1 | USP54 | 0.713592 | 3 | 0 | 3 |
| NUCB1 | ZNF771 | 0.712506 | 3 | 0 | 3 |
| NUCB1 | SYNGR2 | 0.711535 | 4 | 0 | 4 |
| NUCB1 | DYNLRB1 | 0.709497 | 3 | 0 | 3 |
For details and further investigation, click here
