| Full name: protein phosphatase 1 regulatory inhibitor subunit 14A | Alias Symbol: CPI-17 | ||
| Type: protein-coding gene | Cytoband: 19q13.1 | ||
| Entrez ID: 94274 | HGNC ID: HGNC:14871 | Ensembl Gene: ENSG00000167641 | OMIM ID: 608153 |
| Drug and gene relationship at DGIdb | |||
PPP1R14A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04270 | Vascular smooth muscle contraction |
Expression of PPP1R14A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R14A | 94274 | 227006_at | -1.1575 | 0.2981 | |
| GSE26886 | PPP1R14A | 94274 | 227006_at | 1.0233 | 0.0066 | |
| GSE45670 | PPP1R14A | 94274 | 227006_at | -1.9435 | 0.0000 | |
| GSE53622 | PPP1R14A | 94274 | 60618 | -1.0617 | 0.0000 | |
| GSE53624 | PPP1R14A | 94274 | 60618 | -0.9785 | 0.0000 | |
| GSE63941 | PPP1R14A | 94274 | 227006_at | 0.3195 | 0.6164 | |
| GSE77861 | PPP1R14A | 94274 | 227006_at | 0.1966 | 0.4572 | |
| GSE97050 | PPP1R14A | 94274 | A_33_P3335682 | -0.8882 | 0.2151 | |
| SRP007169 | PPP1R14A | 94274 | RNAseq | 1.9025 | 0.0329 | |
| SRP064894 | PPP1R14A | 94274 | RNAseq | -1.2986 | 0.0009 | |
| SRP133303 | PPP1R14A | 94274 | RNAseq | -0.7239 | 0.1907 | |
| SRP159526 | PPP1R14A | 94274 | RNAseq | -1.2407 | 0.0281 | |
| SRP219564 | PPP1R14A | 94274 | RNAseq | -1.2550 | 0.2360 | |
| TCGA | PPP1R14A | 94274 | RNAseq | -0.6124 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 4.
Survival by PPP1R14A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R14A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R14A | 94274 | 7 | 4 | 19 | |
| GSE20123 | PPP1R14A | 94274 | 7 | 3 | 20 | |
| GSE43470 | PPP1R14A | 94274 | 4 | 10 | 29 | |
| GSE46452 | PPP1R14A | 94274 | 47 | 2 | 10 | |
| GSE47630 | PPP1R14A | 94274 | 9 | 5 | 26 | |
| GSE54993 | PPP1R14A | 94274 | 17 | 3 | 50 | |
| GSE54994 | PPP1R14A | 94274 | 6 | 9 | 38 | |
| GSE60625 | PPP1R14A | 94274 | 9 | 0 | 2 | |
| GSE74703 | PPP1R14A | 94274 | 4 | 6 | 26 | |
| GSE74704 | PPP1R14A | 94274 | 7 | 1 | 12 | |
| TCGA | PPP1R14A | 94274 | 18 | 14 | 64 |
Total number of gains: 135; Total number of losses: 57; Total Number of normals: 296.
Somatic mutations of PPP1R14A:
Generating mutation plots.
Highly correlated genes for PPP1R14A:
Showing top 20/853 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R14A | ITGA7 | 0.873654 | 6 | 0 | 6 |
| PPP1R14A | PLA2G5 | 0.869262 | 4 | 0 | 4 |
| PPP1R14A | MYOCD | 0.832835 | 6 | 0 | 6 |
| PPP1R14A | CCDC69 | 0.831951 | 5 | 0 | 5 |
| PPP1R14A | PGR | 0.831443 | 5 | 0 | 5 |
| PPP1R14A | ARHGAP6 | 0.831241 | 5 | 0 | 5 |
| PPP1R14A | MIR100HG | 0.829831 | 5 | 0 | 5 |
| PPP1R14A | TNS1 | 0.825823 | 6 | 0 | 6 |
| PPP1R14A | TMOD1 | 0.821416 | 3 | 0 | 3 |
| PPP1R14A | SCN7A | 0.815797 | 5 | 0 | 5 |
| PPP1R14A | TIMP3 | 0.814191 | 3 | 0 | 3 |
| PPP1R14A | ADAMTS9-AS2 | 0.80955 | 4 | 0 | 4 |
| PPP1R14A | CYP21A2 | 0.807457 | 3 | 0 | 3 |
| PPP1R14A | UBXN10 | 0.806041 | 3 | 0 | 3 |
| PPP1R14A | MICU3 | 0.803933 | 3 | 0 | 3 |
| PPP1R14A | AQP1 | 0.800518 | 6 | 0 | 6 |
| PPP1R14A | CASQ1 | 0.799814 | 4 | 0 | 4 |
| PPP1R14A | ACTBL2 | 0.799164 | 3 | 0 | 3 |
| PPP1R14A | NEXN | 0.799023 | 7 | 0 | 7 |
| PPP1R14A | PDE5A | 0.798729 | 6 | 0 | 6 |
For details and further investigation, click here
