CHD3

 

Full name: chromodomain helicase DNA binding protein 3 Alias Symbol: Mi-2a|ZFH|Mi2-ALPHA
Type: protein-coding gene Cytoband: 17p13.1
Entrez ID: 1107 HGNC ID: HGNC:1918 Ensembl Gene: ENSG00000170004 OMIM ID: 602120
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CHD3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CHD3 1107 208807_s_at 0.8161 0.1520
GSE20347 CHD3 1107 208807_s_at 0.2781 0.0244
GSE23400 CHD3 1107 208807_s_at 0.2694 0.0000
GSE26886 CHD3 1107 208807_s_at 0.6269 0.0008
GSE29001 CHD3 1107 208806_at 0.1473 0.6143
GSE38129 CHD3 1107 208807_s_at 0.2053 0.0860
GSE45670 CHD3 1107 208807_s_at 0.3601 0.0376
GSE53622 CHD3 1107 138472 0.1302 0.1606
GSE53624 CHD3 1107 138472 0.3167 0.0000
GSE63941 CHD3 1107 208807_s_at -0.2705 0.5381
GSE77861 CHD3 1107 208807_s_at 0.3258 0.2075
GSE97050 CHD3 1107 A_33_P3239287 -0.1515 0.5383
SRP007169 CHD3 1107 RNAseq 1.4260 0.0007
SRP008496 CHD3 1107 RNAseq 1.1879 0.0001
SRP064894 CHD3 1107 RNAseq 0.3162 0.0157
SRP133303 CHD3 1107 RNAseq -0.0014 0.9902
SRP159526 CHD3 1107 RNAseq 0.6248 0.0948
SRP193095 CHD3 1107 RNAseq 0.3553 0.0274
SRP219564 CHD3 1107 RNAseq 0.4486 0.1364
TCGA CHD3 1107 RNAseq -0.0269 0.5515

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by CHD3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CHD3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CHD3 1107 4 2 24
GSE20123 CHD3 1107 4 3 23
GSE43470 CHD3 1107 1 6 36
GSE46452 CHD3 1107 34 1 24
GSE47630 CHD3 1107 7 1 32
GSE54993 CHD3 1107 4 3 63
GSE54994 CHD3 1107 5 8 40
GSE60625 CHD3 1107 4 0 7
GSE74703 CHD3 1107 1 3 32
GSE74704 CHD3 1107 2 1 17
TCGA CHD3 1107 17 21 58

Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.  

 

Somatic mutations of CHD3:

 

Generating mutation plots.

 

Highly correlated genes for CHD3:

 

Showing top 20/776 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CHD3BCL7B0.787722303
CHD3DHRSX0.787354303
CHD3PPP1R9B0.783659303
CHD3SCAF10.775318303
CHD3TRAF3IP10.772248303
CHD3SSBP40.771204505
CHD3FAM167B0.765486303
CHD3GMEB20.764218404
CHD3NUDCD10.762825303
CHD3GHDC0.753723303
CHD3ZZEF10.753526404
CHD3TP53I130.74963505
CHD3GRAMD40.748417303
CHD3REC80.745829404
CHD3TMEM2010.74361303
CHD3PTPN230.742349303
CHD3MTCP10.741015303
CHD3ZNF4610.738455303
CHD3GSTO10.738129303
CHD3C17orf670.736641303

For details and further investigation, click here