| Full name: nuclear receptor subfamily 1 group H member 2 | Alias Symbol: NER|NER-I|RIP15|LXR-b|LXRb | ||
| Type: protein-coding gene | Cytoband: 19q13.3 | ||
| Entrez ID: 7376 | HGNC ID: HGNC:7965 | Ensembl Gene: | OMIM ID: 600380 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
NR1H2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04931 | Insulin resistance |
Expression of NR1H2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NR1H2 | 7376 | 218215_s_at | -0.0757 | 0.8850 | |
| GSE20347 | NR1H2 | 7376 | 218215_s_at | -0.2415 | 0.0402 | |
| GSE23400 | NR1H2 | 7376 | 218215_s_at | -0.0471 | 0.4275 | |
| GSE26886 | NR1H2 | 7376 | 218215_s_at | 0.2158 | 0.3654 | |
| GSE29001 | NR1H2 | 7376 | 218215_s_at | -0.0792 | 0.5319 | |
| GSE38129 | NR1H2 | 7376 | 218215_s_at | -0.2803 | 0.0048 | |
| GSE45670 | NR1H2 | 7376 | 218215_s_at | -0.0739 | 0.6036 | |
| GSE63941 | NR1H2 | 7376 | 218215_s_at | 1.5024 | 0.0004 | |
| GSE77861 | NR1H2 | 7376 | 218215_s_at | 0.0327 | 0.9016 | |
| GSE97050 | NR1H2 | 7376 | A_23_P55926 | -0.6390 | 0.0653 | |
| SRP007169 | NR1H2 | 7376 | RNAseq | -0.7898 | 0.0276 | |
| SRP008496 | NR1H2 | 7376 | RNAseq | -0.6486 | 0.0037 | |
| SRP064894 | NR1H2 | 7376 | RNAseq | 0.1936 | 0.4522 | |
| SRP133303 | NR1H2 | 7376 | RNAseq | -0.0196 | 0.9121 | |
| SRP159526 | NR1H2 | 7376 | RNAseq | -0.2340 | 0.2757 | |
| SRP193095 | NR1H2 | 7376 | RNAseq | 0.0208 | 0.8479 | |
| SRP219564 | NR1H2 | 7376 | RNAseq | -0.2152 | 0.5472 | |
| TCGA | NR1H2 | 7376 | RNAseq | -0.0562 | 0.2429 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NR1H2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NR1H2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NR1H2 | 7376 | 4 | 4 | 22 | |
| GSE20123 | NR1H2 | 7376 | 4 | 3 | 23 | |
| GSE43470 | NR1H2 | 7376 | 4 | 11 | 28 | |
| GSE46452 | NR1H2 | 7376 | 45 | 1 | 13 | |
| GSE47630 | NR1H2 | 7376 | 9 | 6 | 25 | |
| GSE54993 | NR1H2 | 7376 | 17 | 4 | 49 | |
| GSE54994 | NR1H2 | 7376 | 4 | 14 | 35 | |
| GSE60625 | NR1H2 | 7376 | 9 | 0 | 2 | |
| GSE74703 | NR1H2 | 7376 | 4 | 7 | 25 | |
| GSE74704 | NR1H2 | 7376 | 4 | 1 | 15 | |
| TCGA | NR1H2 | 7376 | 14 | 19 | 63 |
Total number of gains: 118; Total number of losses: 70; Total Number of normals: 300.
Somatic mutations of NR1H2:
Generating mutation plots.
Highly correlated genes for NR1H2:
Showing top 20/249 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NR1H2 | ZBTB10 | 0.824912 | 3 | 0 | 3 |
| NR1H2 | MAST2 | 0.759059 | 3 | 0 | 3 |
| NR1H2 | ANP32B | 0.756209 | 3 | 0 | 3 |
| NR1H2 | MED22 | 0.754144 | 4 | 0 | 4 |
| NR1H2 | RPS24 | 0.744961 | 3 | 0 | 3 |
| NR1H2 | GEMIN7 | 0.743254 | 3 | 0 | 3 |
| NR1H2 | VPS11 | 0.733398 | 3 | 0 | 3 |
| NR1H2 | ZNF548 | 0.730549 | 3 | 0 | 3 |
| NR1H2 | ABHD8 | 0.729561 | 3 | 0 | 3 |
| NR1H2 | SPHK2 | 0.728143 | 3 | 0 | 3 |
| NR1H2 | RPRD2 | 0.725547 | 4 | 0 | 4 |
| NR1H2 | DIRAS1 | 0.723892 | 3 | 0 | 3 |
| NR1H2 | EPN1 | 0.722699 | 3 | 0 | 3 |
| NR1H2 | ADCK1 | 0.722471 | 3 | 0 | 3 |
| NR1H2 | RHOT1 | 0.721588 | 3 | 0 | 3 |
| NR1H2 | PRSS36 | 0.719838 | 3 | 0 | 3 |
| NR1H2 | WDR48 | 0.718529 | 3 | 0 | 3 |
| NR1H2 | LMBR1 | 0.717474 | 3 | 0 | 3 |
| NR1H2 | SIK1 | 0.716633 | 3 | 0 | 3 |
| NR1H2 | XRRA1 | 0.716025 | 3 | 0 | 3 |
For details and further investigation, click here
