MRGPRX3

 

Full name: MAS related GPR family member X3 Alias Symbol: MRGX3
Type: protein-coding gene Cytoband: 11p15.1
Entrez ID: 117195 HGNC ID: HGNC:17980 Ensembl Gene: ENSG00000179826 OMIM ID: 607229
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MRGPRX3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MRGPRX3 117195 1553293_at 0.1306 0.7835
GSE26886 MRGPRX3 117195 1553293_at 0.3640 0.0107
GSE45670 MRGPRX3 117195 1553293_at 0.4160 0.4493
GSE53622 MRGPRX3 117195 105824 0.1118 0.6478
GSE53624 MRGPRX3 117195 105824 0.6281 0.0008
GSE63941 MRGPRX3 117195 1553293_at 0.0002 0.9996
GSE77861 MRGPRX3 117195 1553293_at 0.0709 0.6694
SRP159526 MRGPRX3 117195 RNAseq 3.6717 0.0000
SRP219564 MRGPRX3 117195 RNAseq -0.1481 0.8310
TCGA MRGPRX3 117195 RNAseq 1.3691 0.0663

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by MRGPRX3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MRGPRX3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRGPRX3 117195 0 10 20
GSE20123 MRGPRX3 117195 0 10 20
GSE43470 MRGPRX3 117195 1 5 37
GSE46452 MRGPRX3 117195 7 5 47
GSE47630 MRGPRX3 117195 3 10 27
GSE54993 MRGPRX3 117195 3 0 67
GSE54994 MRGPRX3 117195 3 12 38
GSE60625 MRGPRX3 117195 0 0 11
GSE74703 MRGPRX3 117195 1 3 32
GSE74704 MRGPRX3 117195 0 9 11
TCGA MRGPRX3 117195 11 29 56

Total number of gains: 29; Total number of losses: 93; Total Number of normals: 366.  

 

Somatic mutations of MRGPRX3:

 

Generating mutation plots.

 

Highly correlated genes for MRGPRX3:

 

Showing all 10 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRGPRX3CALB10.703254303
MRGPRX3ZNF6220.664863404
MRGPRX3SEC61G0.633254303
MRGPRX3C12orf750.630956303
MRGPRX3TGFBR10.614888303
MRGPRX3TMEM1820.612807303
MRGPRX3HSCB0.604608303
MRGPRX3ADSL0.591695303
MRGPRX3CHCHD20.588253303
MRGPRX3NOB10.55832303

For details and further investigation, click here