ADSL

 

Full name: adenylosuccinate lyase Alias Symbol: 
Type: protein-coding gene Cytoband: 22q13.1
Entrez ID: 158 HGNC ID: HGNC:291 Ensembl Gene: ENSG00000239900 OMIM ID: 608222
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ADSL:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADSL 158 210250_x_at 0.3296 0.5327
GSE20347 ADSL 158 202144_s_at 0.6518 0.0004
GSE23400 ADSL 158 210250_x_at 0.6710 0.0000
GSE26886 ADSL 158 202144_s_at 1.2837 0.0000
GSE29001 ADSL 158 202144_s_at 0.6442 0.0250
GSE38129 ADSL 158 202144_s_at 0.5832 0.0000
GSE45670 ADSL 158 202144_s_at 0.3334 0.0798
GSE53622 ADSL 158 2749 0.7680 0.0000
GSE53624 ADSL 158 2749 0.7515 0.0000
GSE63941 ADSL 158 210250_x_at 0.3926 0.3690
GSE77861 ADSL 158 210250_x_at 0.8701 0.0294
GSE97050 ADSL 158 A_23_P155103 0.4972 0.1703
SRP007169 ADSL 158 RNAseq 0.5146 0.1192
SRP008496 ADSL 158 RNAseq 0.5177 0.0115
SRP064894 ADSL 158 RNAseq 0.6516 0.0002
SRP133303 ADSL 158 RNAseq 0.3974 0.0315
SRP159526 ADSL 158 RNAseq 0.7625 0.0042
SRP193095 ADSL 158 RNAseq 0.4352 0.0005
SRP219564 ADSL 158 RNAseq 0.2991 0.4866
TCGA ADSL 158 RNAseq 0.1951 0.0003

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ADSL expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADSL:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADSL 158 6 5 19
GSE20123 ADSL 158 6 4 20
GSE43470 ADSL 158 5 6 32
GSE46452 ADSL 158 31 2 26
GSE47630 ADSL 158 9 4 27
GSE54993 ADSL 158 3 6 61
GSE54994 ADSL 158 9 7 37
GSE60625 ADSL 158 5 0 6
GSE74703 ADSL 158 5 4 27
GSE74704 ADSL 158 3 2 15
TCGA ADSL 158 26 16 54

Total number of gains: 108; Total number of losses: 56; Total Number of normals: 324.  

 

Somatic mutations of ADSL:

 

Generating mutation plots.

 

Highly correlated genes for ADSL:

 

Showing top 20/2235 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADSLRAB340.772495303
ADSLSLC35B20.768041303
ADSLC14orf1190.766485303
ADSLCALCRL0.763327303
ADSLPYCR20.75442303
ADSLSERPINF20.752923303
ADSLTAOK10.751823303
ADSLG2E30.748944505
ADSLTHOC50.74790713012
ADSLHNRNPLL0.747532606
ADSLUSP420.74405505
ADSLJOSD10.74261813013
ADSLPSMA30.740503808
ADSLPRPS10.73489111011
ADSLRNASEH2C0.733537303
ADSLANAPC10.732419303
ADSLCDK40.7315711010
ADSLDNMBP0.728748303
ADSLFBXO50.728285909
ADSLUSF10.725781303

For details and further investigation, click here