| Full name: coiled-coil-helix-coiled-coil-helix domain containing 2 | Alias Symbol: MIX17B|MNRR1 | ||
| Type: protein-coding gene | Cytoband: 7p11.2 | ||
| Entrez ID: 51142 | HGNC ID: HGNC:21645 | Ensembl Gene: ENSG00000106153 | OMIM ID: 616244 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CHCHD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHCHD2 | 51142 | 217720_at | 0.3988 | 0.3362 | |
| GSE20347 | CHCHD2 | 51142 | 217720_at | 0.5965 | 0.0183 | |
| GSE23400 | CHCHD2 | 51142 | 217720_at | 0.4420 | 0.0000 | |
| GSE26886 | CHCHD2 | 51142 | 217720_at | 0.8641 | 0.0000 | |
| GSE29001 | CHCHD2 | 51142 | 217720_at | 0.3599 | 0.3669 | |
| GSE38129 | CHCHD2 | 51142 | 217720_at | 0.6503 | 0.0001 | |
| GSE45670 | CHCHD2 | 51142 | 217720_at | 0.2680 | 0.0154 | |
| GSE63941 | CHCHD2 | 51142 | 217720_at | 1.1148 | 0.0018 | |
| GSE77861 | CHCHD2 | 51142 | 217720_at | 0.2919 | 0.1843 | |
| GSE97050 | CHCHD2 | 51142 | A_24_P400376 | 0.1330 | 0.6190 | |
| SRP007169 | CHCHD2 | 51142 | RNAseq | -0.1239 | 0.7334 | |
| SRP008496 | CHCHD2 | 51142 | RNAseq | 0.3544 | 0.3484 | |
| SRP064894 | CHCHD2 | 51142 | RNAseq | 0.4680 | 0.0826 | |
| SRP133303 | CHCHD2 | 51142 | RNAseq | 0.5162 | 0.0001 | |
| SRP159526 | CHCHD2 | 51142 | RNAseq | 0.5885 | 0.0532 | |
| SRP193095 | CHCHD2 | 51142 | RNAseq | 0.0071 | 0.9665 | |
| SRP219564 | CHCHD2 | 51142 | RNAseq | 0.3234 | 0.1702 | |
| TCGA | CHCHD2 | 51142 | RNAseq | 0.0774 | 0.1871 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CHCHD2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CHCHD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHCHD2 | 51142 | 13 | 0 | 17 | |
| GSE20123 | CHCHD2 | 51142 | 11 | 0 | 19 | |
| GSE43470 | CHCHD2 | 51142 | 5 | 0 | 38 | |
| GSE46452 | CHCHD2 | 51142 | 13 | 0 | 46 | |
| GSE47630 | CHCHD2 | 51142 | 10 | 1 | 29 | |
| GSE54993 | CHCHD2 | 51142 | 0 | 8 | 62 | |
| GSE54994 | CHCHD2 | 51142 | 16 | 2 | 35 | |
| GSE60625 | CHCHD2 | 51142 | 0 | 0 | 11 | |
| GSE74703 | CHCHD2 | 51142 | 5 | 0 | 31 | |
| GSE74704 | CHCHD2 | 51142 | 6 | 0 | 14 | |
| TCGA | CHCHD2 | 51142 | 53 | 5 | 38 |
Total number of gains: 132; Total number of losses: 16; Total Number of normals: 340.
Somatic mutations of CHCHD2:
Generating mutation plots.
Highly correlated genes for CHCHD2:
Showing top 20/1560 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHCHD2 | TCEANC2 | 0.836962 | 3 | 0 | 3 |
| CHCHD2 | CIB1 | 0.816596 | 3 | 0 | 3 |
| CHCHD2 | KRTCAP2 | 0.798155 | 4 | 0 | 4 |
| CHCHD2 | RPS19BP1 | 0.788427 | 4 | 0 | 4 |
| CHCHD2 | DNMBP | 0.768263 | 3 | 0 | 3 |
| CHCHD2 | C12orf65 | 0.761289 | 3 | 0 | 3 |
| CHCHD2 | MRPL55 | 0.753765 | 3 | 0 | 3 |
| CHCHD2 | NTMT1 | 0.751542 | 4 | 0 | 4 |
| CHCHD2 | COQ4 | 0.751542 | 3 | 0 | 3 |
| CHCHD2 | CCT4 | 0.750662 | 9 | 0 | 9 |
| CHCHD2 | CCDC124 | 0.748716 | 4 | 0 | 4 |
| CHCHD2 | PPP1R16A | 0.748495 | 3 | 0 | 3 |
| CHCHD2 | GHDC | 0.74511 | 3 | 0 | 3 |
| CHCHD2 | WDR54 | 0.744063 | 5 | 0 | 5 |
| CHCHD2 | GTPBP3 | 0.74021 | 5 | 0 | 5 |
| CHCHD2 | CCM2 | 0.739648 | 4 | 0 | 4 |
| CHCHD2 | MRPL30 | 0.739416 | 3 | 0 | 3 |
| CHCHD2 | MRPS17 | 0.736339 | 10 | 0 | 9 |
| CHCHD2 | ZFP90 | 0.735671 | 3 | 0 | 3 |
| CHCHD2 | PSMA2 | 0.729463 | 9 | 0 | 9 |
For details and further investigation, click here
