| Full name: SEC61 translocon gamma subunit | Alias Symbol: SSS1 | ||
| Type: protein-coding gene | Cytoband: 7p11.2 | ||
| Entrez ID: 23480 | HGNC ID: HGNC:18277 | Ensembl Gene: ENSG00000132432 | OMIM ID: 609215 |
| Drug and gene relationship at DGIdb | |||
Expression of SEC61G:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC61G | 23480 | 203484_at | 0.1519 | 0.6999 | |
| GSE20347 | SEC61G | 23480 | 203484_at | 0.5944 | 0.0227 | |
| GSE23400 | SEC61G | 23480 | 203484_at | 0.6255 | 0.0000 | |
| GSE26886 | SEC61G | 23480 | 203484_at | 0.2073 | 0.2800 | |
| GSE29001 | SEC61G | 23480 | 203484_at | 0.5392 | 0.1550 | |
| GSE38129 | SEC61G | 23480 | 203484_at | 0.8119 | 0.0000 | |
| GSE45670 | SEC61G | 23480 | 203484_at | 0.5449 | 0.0002 | |
| GSE53622 | SEC61G | 23480 | 14363 | 0.7722 | 0.0000 | |
| GSE53624 | SEC61G | 23480 | 14363 | 0.8696 | 0.0000 | |
| GSE63941 | SEC61G | 23480 | 203484_at | 0.2213 | 0.7239 | |
| GSE77861 | SEC61G | 23480 | 203484_at | 0.2001 | 0.4594 | |
| GSE97050 | SEC61G | 23480 | A_23_P71241 | 0.7138 | 0.1118 | |
| SRP007169 | SEC61G | 23480 | RNAseq | 0.8668 | 0.1938 | |
| SRP008496 | SEC61G | 23480 | RNAseq | 1.6132 | 0.0370 | |
| SRP064894 | SEC61G | 23480 | RNAseq | 1.4559 | 0.0000 | |
| SRP133303 | SEC61G | 23480 | RNAseq | 0.9113 | 0.0001 | |
| SRP159526 | SEC61G | 23480 | RNAseq | 1.0090 | 0.0156 | |
| SRP193095 | SEC61G | 23480 | RNAseq | 0.2811 | 0.2773 | |
| SRP219564 | SEC61G | 23480 | RNAseq | 0.2809 | 0.4458 | |
| TCGA | SEC61G | 23480 | RNAseq | 0.2828 | 0.0019 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SEC61G expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC61G:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC61G | 23480 | 13 | 0 | 17 | |
| GSE20123 | SEC61G | 23480 | 12 | 0 | 18 | |
| GSE43470 | SEC61G | 23480 | 6 | 0 | 37 | |
| GSE46452 | SEC61G | 23480 | 13 | 0 | 46 | |
| GSE47630 | SEC61G | 23480 | 10 | 1 | 29 | |
| GSE54993 | SEC61G | 23480 | 0 | 12 | 58 | |
| GSE54994 | SEC61G | 23480 | 18 | 1 | 34 | |
| GSE60625 | SEC61G | 23480 | 0 | 0 | 11 | |
| GSE74703 | SEC61G | 23480 | 6 | 0 | 30 | |
| GSE74704 | SEC61G | 23480 | 6 | 0 | 14 | |
| TCGA | SEC61G | 23480 | 56 | 6 | 34 |
Total number of gains: 140; Total number of losses: 20; Total Number of normals: 328.
Somatic mutations of SEC61G:
Generating mutation plots.
Highly correlated genes for SEC61G:
Showing top 20/965 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC61G | MILR1 | 0.77225 | 3 | 0 | 3 |
| SEC61G | MRPL30 | 0.76606 | 3 | 0 | 3 |
| SEC61G | TMEM54 | 0.735542 | 3 | 0 | 3 |
| SEC61G | HIP1 | 0.733923 | 3 | 0 | 3 |
| SEC61G | N4BP1 | 0.729344 | 3 | 0 | 3 |
| SEC61G | LYPD5 | 0.727854 | 3 | 0 | 3 |
| SEC61G | PCSK1 | 0.724125 | 3 | 0 | 3 |
| SEC61G | UBA52 | 0.718271 | 3 | 0 | 3 |
| SEC61G | MICALCL | 0.715637 | 3 | 0 | 3 |
| SEC61G | AMPD3 | 0.70665 | 3 | 0 | 3 |
| SEC61G | CHCHD2 | 0.700589 | 11 | 0 | 10 |
| SEC61G | TMEM65 | 0.700477 | 4 | 0 | 4 |
| SEC61G | PDE7A | 0.699636 | 3 | 0 | 3 |
| SEC61G | NIPBL | 0.699155 | 3 | 0 | 3 |
| SEC61G | HSPBP1 | 0.694909 | 3 | 0 | 3 |
| SEC61G | POLR2K | 0.693683 | 6 | 0 | 5 |
| SEC61G | MTHFD1L | 0.692421 | 3 | 0 | 3 |
| SEC61G | TMEM167A | 0.684561 | 5 | 0 | 4 |
| SEC61G | CCT6A | 0.680443 | 10 | 0 | 8 |
| SEC61G | JKAMP | 0.679497 | 6 | 0 | 5 |
For details and further investigation, click here
