| Full name: HscB mitochondrial iron-sulfur cluster cochaperone | Alias Symbol: HSC20|DNAJC20|Jac1 | ||
| Type: protein-coding gene | Cytoband: 22q12.1 | ||
| Entrez ID: 150274 | HGNC ID: HGNC:28913 | Ensembl Gene: ENSG00000100209 | OMIM ID: 608142 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HSCB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSCB | 150274 | 223647_x_at | -0.0936 | 0.8577 | |
| GSE26886 | HSCB | 150274 | 223647_x_at | 0.8271 | 0.0000 | |
| GSE45670 | HSCB | 150274 | 223647_x_at | 0.2256 | 0.0868 | |
| GSE53622 | HSCB | 150274 | 26437 | 0.8503 | 0.0000 | |
| GSE53624 | HSCB | 150274 | 26437 | 0.7564 | 0.0000 | |
| GSE63941 | HSCB | 150274 | 223647_x_at | -0.3912 | 0.3501 | |
| GSE77861 | HSCB | 150274 | 223647_x_at | 0.2599 | 0.2692 | |
| GSE97050 | HSCB | 150274 | A_33_P3309231 | 0.6449 | 0.0684 | |
| SRP007169 | HSCB | 150274 | RNAseq | 0.7226 | 0.1384 | |
| SRP008496 | HSCB | 150274 | RNAseq | 0.5398 | 0.1196 | |
| SRP064894 | HSCB | 150274 | RNAseq | 0.4471 | 0.0596 | |
| SRP133303 | HSCB | 150274 | RNAseq | 0.0526 | 0.7614 | |
| SRP159526 | HSCB | 150274 | RNAseq | 0.1797 | 0.4039 | |
| SRP193095 | HSCB | 150274 | RNAseq | 0.1027 | 0.3341 | |
| SRP219564 | HSCB | 150274 | RNAseq | -0.1040 | 0.7385 | |
| TCGA | HSCB | 150274 | RNAseq | -0.0288 | 0.6817 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSCB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSCB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSCB | 150274 | 3 | 3 | 24 | |
| GSE20123 | HSCB | 150274 | 3 | 2 | 25 | |
| GSE43470 | HSCB | 150274 | 3 | 6 | 34 | |
| GSE46452 | HSCB | 150274 | 31 | 1 | 27 | |
| GSE47630 | HSCB | 150274 | 8 | 5 | 27 | |
| GSE54993 | HSCB | 150274 | 3 | 6 | 61 | |
| GSE54994 | HSCB | 150274 | 11 | 8 | 34 | |
| GSE60625 | HSCB | 150274 | 5 | 0 | 6 | |
| GSE74703 | HSCB | 150274 | 3 | 5 | 28 | |
| GSE74704 | HSCB | 150274 | 0 | 1 | 19 | |
| TCGA | HSCB | 150274 | 27 | 15 | 54 |
Total number of gains: 97; Total number of losses: 52; Total Number of normals: 339.
Somatic mutations of HSCB:
Generating mutation plots.
Highly correlated genes for HSCB:
Showing top 20/196 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSCB | BCYRN1 | 0.854109 | 3 | 0 | 3 |
| HSCB | RBM28 | 0.712489 | 3 | 0 | 3 |
| HSCB | HSD17B7 | 0.683613 | 5 | 0 | 4 |
| HSCB | NFKBIE | 0.680676 | 3 | 0 | 3 |
| HSCB | POSTN | 0.680446 | 4 | 0 | 4 |
| HSCB | FIP1L1 | 0.673502 | 4 | 0 | 3 |
| HSCB | RAX2 | 0.668793 | 4 | 0 | 3 |
| HSCB | COL3A1 | 0.663062 | 4 | 0 | 4 |
| HSCB | ZNF160 | 0.662646 | 5 | 0 | 4 |
| HSCB | XRCC2 | 0.652969 | 7 | 0 | 6 |
| HSCB | CCNB1IP1 | 0.652477 | 4 | 0 | 4 |
| HSCB | CD44 | 0.648318 | 3 | 0 | 3 |
| HSCB | MIPOL1 | 0.639471 | 4 | 0 | 3 |
| HSCB | LAMC2 | 0.639168 | 5 | 0 | 4 |
| HSCB | FADD | 0.63725 | 3 | 0 | 3 |
| HSCB | ADAM12 | 0.633398 | 3 | 0 | 3 |
| HSCB | NOP14 | 0.629393 | 3 | 0 | 3 |
| HSCB | PLOD1 | 0.626315 | 3 | 0 | 3 |
| HSCB | EXT1 | 0.624366 | 5 | 0 | 3 |
| HSCB | SLC35E1 | 0.622416 | 5 | 0 | 4 |
For details and further investigation, click here
