TGFBR1

 

Full name: transforming growth factor beta receptor 1 Alias Symbol: ALK-5|ACVRLK4|ALK5|TBRI|TBR-i
Type: protein-coding gene Cytoband: 9q22.33
Entrez ID: 7046 HGNC ID: HGNC:11772 Ensembl Gene: ENSG00000106799 OMIM ID: 190181
Drug and gene relationship at DGIdb
Screen Evidence:

 

TGFBR1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04068FoxO signaling pathway
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04390Hippo signaling pathway
hsa04520Adherens junction
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05142Chagas disease (American trypanosomiasis)
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia

 

Expression of TGFBR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TGFBR1 7046 224793_s_at 0.2637 0.6383
GSE20347 TGFBR1 7046 206943_at 0.1047 0.1500
GSE23400 TGFBR1 7046 206943_at 0.0791 0.0348
GSE26886 TGFBR1 7046 224793_s_at 0.8763 0.0015
GSE29001 TGFBR1 7046 206943_at 0.1356 0.4185
GSE38129 TGFBR1 7046 206943_at 0.1040 0.1229
GSE45670 TGFBR1 7046 224793_s_at 0.1201 0.6281
GSE53622 TGFBR1 7046 12553 0.1891 0.0608
GSE53624 TGFBR1 7046 12553 0.4466 0.0000
GSE63941 TGFBR1 7046 224793_s_at -1.7963 0.0041
GSE77861 TGFBR1 7046 224793_s_at 0.4475 0.2532
GSE97050 TGFBR1 7046 A_33_P3331451 0.1960 0.4245
SRP007169 TGFBR1 7046 RNAseq 1.2565 0.0031
SRP008496 TGFBR1 7046 RNAseq 0.9902 0.0000
SRP064894 TGFBR1 7046 RNAseq 0.4488 0.0309
SRP133303 TGFBR1 7046 RNAseq 0.8367 0.0009
SRP159526 TGFBR1 7046 RNAseq -0.0113 0.9636
SRP193095 TGFBR1 7046 RNAseq 0.3771 0.0250
SRP219564 TGFBR1 7046 RNAseq 0.4548 0.2070
TCGA TGFBR1 7046 RNAseq -0.0647 0.2800

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by TGFBR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TGFBR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TGFBR1 7046 5 9 16
GSE20123 TGFBR1 7046 5 8 17
GSE43470 TGFBR1 7046 6 3 34
GSE46452 TGFBR1 7046 6 13 40
GSE47630 TGFBR1 7046 1 17 22
GSE54993 TGFBR1 7046 3 3 64
GSE54994 TGFBR1 7046 8 11 34
GSE60625 TGFBR1 7046 0 0 11
GSE74703 TGFBR1 7046 5 3 28
GSE74704 TGFBR1 7046 3 5 12
TCGA TGFBR1 7046 27 22 47

Total number of gains: 69; Total number of losses: 94; Total Number of normals: 325.  

 

Somatic mutations of TGFBR1:

 

Generating mutation plots.

 

Highly correlated genes for TGFBR1:

 

Showing top 20/644 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TGFBR1MBNL20.772728303
TGFBR1UBTD20.761793404
TGFBR1KDM6B0.758001303
TGFBR1TPCN20.756334303
TGFBR1MTMR60.752874303
TGFBR1PLEKHB20.747661303
TGFBR1VOPP10.744329303
TGFBR1TMEM1350.743868303
TGFBR1PPP1R210.739365303
TGFBR1SIAH10.738861303
TGFBR1STAG20.730736303
TGFBR1IDS0.725074303
TGFBR1USP120.721404303
TGFBR1NPHP30.720556303
TGFBR1TRAF3IP10.719112404
TGFBR1SF3A20.718863303
TGFBR1PRDM50.71868303
TGFBR1DOCK50.716993504
TGFBR1KIAA08950.710873303
TGFBR1C19orf540.709501303

For details and further investigation, click here