MRPL53

 

Full name: mitochondrial ribosomal protein L53 Alias Symbol: 
Type: protein-coding gene Cytoband: 2p13.1
Entrez ID: 116540 HGNC ID: HGNC:16684 Ensembl Gene: ENSG00000204822 OMIM ID: 611857
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MRPL53:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 MRPL53 116540 18835 0.1433 0.0043
GSE53624 MRPL53 116540 18835 0.3245 0.0000
GSE97050 MRPL53 116540 A_23_P102258 0.3652 0.2576
SRP007169 MRPL53 116540 RNAseq -0.4872 0.2224
SRP008496 MRPL53 116540 RNAseq -0.3038 0.3042
SRP064894 MRPL53 116540 RNAseq 0.1453 0.6580
SRP133303 MRPL53 116540 RNAseq 0.1067 0.3827
SRP159526 MRPL53 116540 RNAseq 0.4341 0.0922
SRP193095 MRPL53 116540 RNAseq -0.2066 0.1255
SRP219564 MRPL53 116540 RNAseq -0.0295 0.8751
TCGA MRPL53 116540 RNAseq 0.0311 0.6722

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MRPL53 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MRPL53:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRPL53 116540 9 2 19
GSE20123 MRPL53 116540 10 2 18
GSE43470 MRPL53 116540 4 0 39
GSE46452 MRPL53 116540 2 3 54
GSE47630 MRPL53 116540 7 0 33
GSE54993 MRPL53 116540 0 6 64
GSE54994 MRPL53 116540 10 0 43
GSE60625 MRPL53 116540 0 3 8
GSE74703 MRPL53 116540 4 0 32
GSE74704 MRPL53 116540 8 0 12
TCGA MRPL53 116540 37 2 57

Total number of gains: 91; Total number of losses: 18; Total Number of normals: 379.  

 

Somatic mutations of MRPL53:

 

Generating mutation plots.

 

Highly correlated genes for MRPL53:

 

Showing all 10 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRPL53RBMX0.739494303
MRPL53EIF4E20.705759303
MRPL53COPS60.700944303
MRPL53MRPL240.694949303
MRPL53TAF100.673972303
MRPL53JMJD40.648469403
MRPL53COX5B0.618513303
MRPL53GEMIN60.602949403
MRPL53CCT70.551978303
MRPL53PCGF10.516447403

For details and further investigation, click here