PCGF1

 

Full name: polycomb group ring finger 1 Alias Symbol: NSPC1|RNF68|MGC10882
Type: protein-coding gene Cytoband: 2p13.1
Entrez ID: 84759 HGNC ID: HGNC:17615 Ensembl Gene: ENSG00000115289 OMIM ID: 610231
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PCGF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PCGF1 84759 210023_s_at 0.5229 0.1726
GSE20347 PCGF1 84759 210022_at 0.4303 0.0002
GSE23400 PCGF1 84759 210023_s_at 0.5420 0.0000
GSE26886 PCGF1 84759 210022_at -0.0083 0.9670
GSE29001 PCGF1 84759 210022_at 0.2570 0.1448
GSE38129 PCGF1 84759 210022_at 0.3164 0.0001
GSE45670 PCGF1 84759 210022_at 0.2242 0.0185
GSE53622 PCGF1 84759 2908 0.7250 0.0000
GSE53624 PCGF1 84759 2908 0.8034 0.0000
GSE63941 PCGF1 84759 210022_at 0.7961 0.0405
GSE77861 PCGF1 84759 210023_s_at 0.6776 0.0164
GSE97050 PCGF1 84759 A_23_P68059 0.4819 0.1321
SRP007169 PCGF1 84759 RNAseq -0.0143 0.9728
SRP008496 PCGF1 84759 RNAseq -0.1008 0.7438
SRP064894 PCGF1 84759 RNAseq 0.8603 0.0001
SRP133303 PCGF1 84759 RNAseq 0.6530 0.0002
SRP159526 PCGF1 84759 RNAseq 1.0599 0.0000
SRP193095 PCGF1 84759 RNAseq 0.4928 0.0001
SRP219564 PCGF1 84759 RNAseq 0.9158 0.0534
TCGA PCGF1 84759 RNAseq 0.2991 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PCGF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PCGF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PCGF1 84759 9 2 19
GSE20123 PCGF1 84759 10 2 18
GSE43470 PCGF1 84759 4 0 39
GSE46452 PCGF1 84759 2 3 54
GSE47630 PCGF1 84759 7 0 33
GSE54993 PCGF1 84759 0 6 64
GSE54994 PCGF1 84759 10 0 43
GSE60625 PCGF1 84759 0 3 8
GSE74703 PCGF1 84759 4 0 32
GSE74704 PCGF1 84759 8 0 12
TCGA PCGF1 84759 37 2 57

Total number of gains: 91; Total number of losses: 18; Total Number of normals: 379.  

 

Somatic mutations of PCGF1:

 

Generating mutation plots.

 

Highly correlated genes for PCGF1:

 

Showing top 20/1321 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PCGF1WDR540.737738505
PCGF1SNAP470.737263303
PCGF1NOP560.736775303
PCGF1PYCR20.731173303
PCGF1SPC240.725492404
PCGF1FMNL20.720168505
PCGF1INO80B0.709342605
PCGF1GALNT180.704636504
PCGF1TTYH30.704544605
PCGF1GGT50.703185303
PCGF1HTRA20.693875807
PCGF1SLC3A20.6921921009
PCGF1FAM89A0.691004303
PCGF1AATF0.688279908
PCGF1SEMA4F0.686991009
PCGF1CAGE10.686204404
PCGF1TOP1MT0.685669505
PCGF1IGSF80.685119505
PCGF1TGFB10.682995403
PCGF1PSMG30.679229605

For details and further investigation, click here