GEMIN6

 

Full name: gem nuclear organelle associated protein 6 Alias Symbol: FLJ23459
Type: protein-coding gene Cytoband: 2p22.1
Entrez ID: 79833 HGNC ID: HGNC:20044 Ensembl Gene: ENSG00000152147 OMIM ID: 607006
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of GEMIN6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GEMIN6 79833 219539_at 0.6043 0.1930
GSE20347 GEMIN6 79833 219539_at 0.8061 0.0001
GSE23400 GEMIN6 79833 219539_at 0.5214 0.0000
GSE26886 GEMIN6 79833 219539_at 0.7717 0.0000
GSE29001 GEMIN6 79833 219539_at 0.8018 0.0197
GSE38129 GEMIN6 79833 219539_at 0.8191 0.0000
GSE45670 GEMIN6 79833 219539_at 0.6559 0.0006
GSE53622 GEMIN6 79833 54370 0.7042 0.0000
GSE53624 GEMIN6 79833 54370 1.0300 0.0000
GSE63941 GEMIN6 79833 219539_at 0.8156 0.0628
GSE77861 GEMIN6 79833 219539_at 0.5377 0.0100
GSE97050 GEMIN6 79833 A_23_P56567 0.6784 0.1552
SRP007169 GEMIN6 79833 RNAseq 0.1962 0.6418
SRP008496 GEMIN6 79833 RNAseq 0.8002 0.0040
SRP064894 GEMIN6 79833 RNAseq 0.6438 0.0030
SRP133303 GEMIN6 79833 RNAseq 0.1939 0.1017
SRP159526 GEMIN6 79833 RNAseq 0.7059 0.0206
SRP193095 GEMIN6 79833 RNAseq 0.1969 0.0494
SRP219564 GEMIN6 79833 RNAseq 0.6268 0.1133
TCGA GEMIN6 79833 RNAseq 0.2669 0.0008

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by GEMIN6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GEMIN6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GEMIN6 79833 11 1 18
GSE20123 GEMIN6 79833 10 1 19
GSE43470 GEMIN6 79833 3 0 40
GSE46452 GEMIN6 79833 1 4 54
GSE47630 GEMIN6 79833 7 0 33
GSE54993 GEMIN6 79833 0 5 65
GSE54994 GEMIN6 79833 10 0 43
GSE60625 GEMIN6 79833 0 3 8
GSE74703 GEMIN6 79833 3 0 33
GSE74704 GEMIN6 79833 9 1 10
TCGA GEMIN6 79833 35 3 58

Total number of gains: 89; Total number of losses: 18; Total Number of normals: 381.  

 

Somatic mutations of GEMIN6:

 

Generating mutation plots.

 

Highly correlated genes for GEMIN6:

 

Showing top 20/2027 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GEMIN6CAD0.7618712012
GEMIN6KNSTRN0.760289707
GEMIN6CENPN0.74953613013
GEMIN6DEPDC1B0.748914707
GEMIN6SCNM10.743879303
GEMIN6PSME40.74380511011
GEMIN6CKS1B0.74344712012
GEMIN6C6orf1410.741298303
GEMIN6ZNF7070.74004303
GEMIN6CENPA0.73854812012
GEMIN6PFDN20.73511010
GEMIN6PTCD10.734975303
GEMIN6CMSS10.734349606
GEMIN6TPX20.73254412012
GEMIN6CPSF30.732518908
GEMIN6PNO10.732332707
GEMIN6MCM60.73153613012
GEMIN6EFTUD20.72922707
GEMIN6PSMA70.72840910010
GEMIN6UBE2C0.72746113012

For details and further investigation, click here