| Full name: COP9 signalosome subunit 6 | Alias Symbol: MOV34-34KD|CSN6 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 10980 | HGNC ID: HGNC:21749 | Ensembl Gene: ENSG00000168090 | OMIM ID: 614729 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COPS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPS6 | 10980 | 201405_s_at | -0.2233 | 0.3417 | |
| GSE20347 | COPS6 | 10980 | 201405_s_at | -0.1799 | 0.3390 | |
| GSE23400 | COPS6 | 10980 | 201405_s_at | -0.0936 | 0.2562 | |
| GSE26886 | COPS6 | 10980 | 201405_s_at | -0.4526 | 0.0279 | |
| GSE29001 | COPS6 | 10980 | 213504_at | -0.4730 | 0.0198 | |
| GSE38129 | COPS6 | 10980 | 201405_s_at | -0.0588 | 0.6724 | |
| GSE45670 | COPS6 | 10980 | 201405_s_at | -0.0527 | 0.7807 | |
| GSE53622 | COPS6 | 10980 | 21783 | -0.0145 | 0.8441 | |
| GSE53624 | COPS6 | 10980 | 21783 | 0.1998 | 0.0001 | |
| GSE63941 | COPS6 | 10980 | 201405_s_at | 0.2085 | 0.6837 | |
| GSE77861 | COPS6 | 10980 | 201405_s_at | -0.1387 | 0.3411 | |
| GSE97050 | COPS6 | 10980 | A_23_P8432 | 0.1923 | 0.5613 | |
| SRP007169 | COPS6 | 10980 | RNAseq | -1.2624 | 0.0002 | |
| SRP008496 | COPS6 | 10980 | RNAseq | -0.7386 | 0.0085 | |
| SRP064894 | COPS6 | 10980 | RNAseq | -0.0144 | 0.9516 | |
| SRP133303 | COPS6 | 10980 | RNAseq | 0.0974 | 0.5205 | |
| SRP159526 | COPS6 | 10980 | RNAseq | -0.0514 | 0.7970 | |
| SRP193095 | COPS6 | 10980 | RNAseq | -0.0420 | 0.7588 | |
| SRP219564 | COPS6 | 10980 | RNAseq | -0.1865 | 0.4951 | |
| TCGA | COPS6 | 10980 | RNAseq | 0.1190 | 0.0170 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by COPS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPS6 | 10980 | 13 | 0 | 17 | |
| GSE20123 | COPS6 | 10980 | 13 | 0 | 17 | |
| GSE43470 | COPS6 | 10980 | 6 | 2 | 35 | |
| GSE46452 | COPS6 | 10980 | 11 | 1 | 47 | |
| GSE47630 | COPS6 | 10980 | 7 | 3 | 30 | |
| GSE54993 | COPS6 | 10980 | 1 | 9 | 60 | |
| GSE54994 | COPS6 | 10980 | 16 | 3 | 34 | |
| GSE60625 | COPS6 | 10980 | 0 | 0 | 11 | |
| GSE74703 | COPS6 | 10980 | 6 | 1 | 29 | |
| GSE74704 | COPS6 | 10980 | 9 | 0 | 11 | |
| TCGA | COPS6 | 10980 | 52 | 6 | 38 |
Total number of gains: 134; Total number of losses: 25; Total Number of normals: 329.
Somatic mutations of COPS6:
Generating mutation plots.
Highly correlated genes for COPS6:
Showing top 20/353 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPS6 | AK3 | 0.741592 | 3 | 0 | 3 |
| COPS6 | UBE4A | 0.740832 | 3 | 0 | 3 |
| COPS6 | KIF13B | 0.734394 | 3 | 0 | 3 |
| COPS6 | PDGFRA | 0.723223 | 3 | 0 | 3 |
| COPS6 | PNPLA8 | 0.709028 | 3 | 0 | 3 |
| COPS6 | C11orf54 | 0.705319 | 3 | 0 | 3 |
| COPS6 | MRPL53 | 0.700944 | 3 | 0 | 3 |
| COPS6 | FAM122A | 0.699517 | 3 | 0 | 3 |
| COPS6 | SPRY1 | 0.694779 | 3 | 0 | 3 |
| COPS6 | ARRDC3 | 0.691945 | 3 | 0 | 3 |
| COPS6 | MTFMT | 0.689581 | 3 | 0 | 3 |
| COPS6 | FBXO8 | 0.687284 | 3 | 0 | 3 |
| COPS6 | SRP14 | 0.686689 | 5 | 0 | 4 |
| COPS6 | LYSMD3 | 0.68342 | 3 | 0 | 3 |
| COPS6 | YAP1 | 0.683403 | 4 | 0 | 4 |
| COPS6 | RPL14 | 0.677096 | 3 | 0 | 3 |
| COPS6 | VPS4B | 0.676125 | 3 | 0 | 3 |
| COPS6 | TPRG1L | 0.675973 | 3 | 0 | 3 |
| COPS6 | HOOK3 | 0.675417 | 4 | 0 | 4 |
| COPS6 | SNRK | 0.675383 | 3 | 0 | 3 |
For details and further investigation, click here
