| Full name: cytochrome c oxidase subunit 5B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 1329 | HGNC ID: HGNC:2269 | Ensembl Gene: ENSG00000135940 | OMIM ID: 123866 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX5B | 1329 | 213735_s_at | 0.0813 | 0.7869 | |
| GSE20347 | COX5B | 1329 | 213735_s_at | -0.2738 | 0.0575 | |
| GSE23400 | COX5B | 1329 | 213735_s_at | -0.0968 | 0.1754 | |
| GSE26886 | COX5B | 1329 | 213735_s_at | 0.1720 | 0.2603 | |
| GSE29001 | COX5B | 1329 | 213735_s_at | -0.2136 | 0.3085 | |
| GSE38129 | COX5B | 1329 | 213735_s_at | -0.1633 | 0.1343 | |
| GSE45670 | COX5B | 1329 | 213735_s_at | -0.0334 | 0.8564 | |
| GSE53622 | COX5B | 1329 | 26325 | -0.4694 | 0.0000 | |
| GSE53624 | COX5B | 1329 | 26325 | -0.1101 | 0.1020 | |
| GSE63941 | COX5B | 1329 | 213735_s_at | 0.7528 | 0.0328 | |
| GSE77861 | COX5B | 1329 | 213735_s_at | -0.1073 | 0.6251 | |
| GSE97050 | COX5B | 1329 | A_33_P3274851 | -0.3960 | 0.1785 | |
| SRP007169 | COX5B | 1329 | RNAseq | -0.9061 | 0.0062 | |
| SRP008496 | COX5B | 1329 | RNAseq | -0.8962 | 0.0001 | |
| SRP064894 | COX5B | 1329 | RNAseq | -0.0891 | 0.7758 | |
| SRP133303 | COX5B | 1329 | RNAseq | -0.0190 | 0.8986 | |
| SRP159526 | COX5B | 1329 | RNAseq | 0.3739 | 0.1974 | |
| SRP193095 | COX5B | 1329 | RNAseq | -0.9299 | 0.0000 | |
| SRP219564 | COX5B | 1329 | RNAseq | -0.3583 | 0.3671 | |
| TCGA | COX5B | 1329 | RNAseq | -0.0883 | 0.1557 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COX5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX5B | 1329 | 6 | 2 | 22 | |
| GSE20123 | COX5B | 1329 | 6 | 2 | 22 | |
| GSE43470 | COX5B | 1329 | 3 | 3 | 37 | |
| GSE46452 | COX5B | 1329 | 2 | 3 | 54 | |
| GSE47630 | COX5B | 1329 | 7 | 0 | 33 | |
| GSE54993 | COX5B | 1329 | 0 | 6 | 64 | |
| GSE54994 | COX5B | 1329 | 11 | 0 | 42 | |
| GSE60625 | COX5B | 1329 | 0 | 3 | 8 | |
| GSE74703 | COX5B | 1329 | 3 | 2 | 31 | |
| GSE74704 | COX5B | 1329 | 4 | 1 | 15 | |
| TCGA | COX5B | 1329 | 35 | 3 | 58 |
Total number of gains: 77; Total number of losses: 25; Total Number of normals: 386.
Somatic mutations of COX5B:
Generating mutation plots.
Highly correlated genes for COX5B:
Showing top 20/383 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX5B | INO80E | 0.740196 | 3 | 0 | 3 |
| COX5B | SERF2 | 0.719522 | 3 | 0 | 3 |
| COX5B | UBE2N | 0.718384 | 3 | 0 | 3 |
| COX5B | NDUFA12 | 0.715224 | 4 | 0 | 4 |
| COX5B | GBA2 | 0.709752 | 3 | 0 | 3 |
| COX5B | C2orf76 | 0.70579 | 3 | 0 | 3 |
| COX5B | COBLL1 | 0.702342 | 3 | 0 | 3 |
| COX5B | ANAPC13 | 0.68299 | 3 | 0 | 3 |
| COX5B | DDX18 | 0.682028 | 4 | 0 | 3 |
| COX5B | GLYR1 | 0.671719 | 4 | 0 | 3 |
| COX5B | CCNDBP1 | 0.671654 | 4 | 0 | 4 |
| COX5B | COA5 | 0.669903 | 5 | 0 | 4 |
| COX5B | AGK | 0.667867 | 3 | 0 | 3 |
| COX5B | EIF1AX | 0.664706 | 3 | 0 | 3 |
| COX5B | CETN2 | 0.66396 | 4 | 0 | 4 |
| COX5B | MAP1S | 0.662386 | 3 | 0 | 3 |
| COX5B | UQCR10 | 0.660296 | 8 | 0 | 6 |
| COX5B | IDH1 | 0.660091 | 3 | 0 | 3 |
| COX5B | ALAS1 | 0.656133 | 4 | 0 | 4 |
| COX5B | CARS2 | 0.656003 | 3 | 0 | 3 |
For details and further investigation, click here
