| Full name: eukaryotic translation initiation factor 4E family member 2 | Alias Symbol: IF4e|4EHP | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 9470 | HGNC ID: HGNC:3293 | Ensembl Gene: ENSG00000135930 | OMIM ID: 605895 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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EIF4E2 involved pathways:
Expression of EIF4E2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4E2 | 9470 | 213571_s_at | -0.3499 | 0.4969 | |
| GSE20347 | EIF4E2 | 9470 | 213571_s_at | -0.4882 | 0.0008 | |
| GSE23400 | EIF4E2 | 9470 | 213571_s_at | 0.0123 | 0.9012 | |
| GSE26886 | EIF4E2 | 9470 | 213571_s_at | -0.3959 | 0.0501 | |
| GSE29001 | EIF4E2 | 9470 | 213571_s_at | -0.2391 | 0.1441 | |
| GSE38129 | EIF4E2 | 9470 | 213571_s_at | -0.1263 | 0.4837 | |
| GSE45670 | EIF4E2 | 9470 | 213571_s_at | 0.1322 | 0.3574 | |
| GSE53622 | EIF4E2 | 9470 | 102931 | -0.0847 | 0.1374 | |
| GSE53624 | EIF4E2 | 9470 | 102931 | 0.1963 | 0.0000 | |
| GSE63941 | EIF4E2 | 9470 | 213571_s_at | -0.0270 | 0.9525 | |
| GSE77861 | EIF4E2 | 9470 | 213571_s_at | 0.0088 | 0.9748 | |
| GSE97050 | EIF4E2 | 9470 | A_33_P3308050 | 0.1771 | 0.4116 | |
| SRP007169 | EIF4E2 | 9470 | RNAseq | -0.1341 | 0.7497 | |
| SRP008496 | EIF4E2 | 9470 | RNAseq | -0.0096 | 0.9692 | |
| SRP064894 | EIF4E2 | 9470 | RNAseq | 0.2924 | 0.2548 | |
| SRP133303 | EIF4E2 | 9470 | RNAseq | 0.0319 | 0.7996 | |
| SRP159526 | EIF4E2 | 9470 | RNAseq | -0.1542 | 0.3429 | |
| SRP193095 | EIF4E2 | 9470 | RNAseq | -0.4112 | 0.0005 | |
| SRP219564 | EIF4E2 | 9470 | RNAseq | -0.0318 | 0.9124 | |
| TCGA | EIF4E2 | 9470 | RNAseq | -0.0657 | 0.1601 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF4E2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4E2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4E2 | 9470 | 1 | 12 | 17 | |
| GSE20123 | EIF4E2 | 9470 | 1 | 12 | 17 | |
| GSE43470 | EIF4E2 | 9470 | 1 | 8 | 34 | |
| GSE46452 | EIF4E2 | 9470 | 0 | 5 | 54 | |
| GSE47630 | EIF4E2 | 9470 | 4 | 5 | 31 | |
| GSE54993 | EIF4E2 | 9470 | 3 | 2 | 65 | |
| GSE54994 | EIF4E2 | 9470 | 6 | 10 | 37 | |
| GSE60625 | EIF4E2 | 9470 | 0 | 3 | 8 | |
| GSE74703 | EIF4E2 | 9470 | 1 | 6 | 29 | |
| GSE74704 | EIF4E2 | 9470 | 1 | 5 | 14 | |
| TCGA | EIF4E2 | 9470 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 97; Total Number of normals: 362.
Somatic mutations of EIF4E2:
Generating mutation plots.
Highly correlated genes for EIF4E2:
Showing top 20/452 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4E2 | TTC39B | 0.777026 | 3 | 0 | 3 |
| EIF4E2 | ABI1 | 0.770795 | 3 | 0 | 3 |
| EIF4E2 | TMCC3 | 0.741883 | 3 | 0 | 3 |
| EIF4E2 | RB1 | 0.733221 | 3 | 0 | 3 |
| EIF4E2 | SEC24B | 0.732885 | 3 | 0 | 3 |
| EIF4E2 | DAAM1 | 0.725062 | 3 | 0 | 3 |
| EIF4E2 | ANAPC13 | 0.706402 | 3 | 0 | 3 |
| EIF4E2 | MRPL53 | 0.705759 | 3 | 0 | 3 |
| EIF4E2 | CLCC1 | 0.705372 | 3 | 0 | 3 |
| EIF4E2 | ATP11B | 0.700256 | 4 | 0 | 3 |
| EIF4E2 | NUDT5 | 0.693294 | 3 | 0 | 3 |
| EIF4E2 | ARFGEF2 | 0.691693 | 3 | 0 | 3 |
| EIF4E2 | EPN1 | 0.691113 | 3 | 0 | 3 |
| EIF4E2 | ATP6V1G1 | 0.689786 | 5 | 0 | 4 |
| EIF4E2 | UEVLD | 0.680339 | 3 | 0 | 3 |
| EIF4E2 | SET | 0.678305 | 3 | 0 | 3 |
| EIF4E2 | KCTD11 | 0.676068 | 4 | 0 | 4 |
| EIF4E2 | SUSD1 | 0.670929 | 3 | 0 | 3 |
| EIF4E2 | LDHD | 0.670644 | 3 | 0 | 3 |
| EIF4E2 | IL10RB | 0.667924 | 5 | 0 | 4 |
For details and further investigation, click here
