| Full name: myosin heavy chain 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 4624 | HGNC ID: HGNC:7576 | Ensembl Gene: ENSG00000197616 | OMIM ID: 160710 |
| Drug and gene relationship at DGIdb | |||
MYH6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04530 | Tight junction | |
| hsa04919 | Thyroid hormone signaling pathway |
Expression of MYH6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH6 | 4624 | 214468_at | 0.1236 | 0.5885 | |
| GSE20347 | MYH6 | 4624 | 214468_at | -0.1380 | 0.0066 | |
| GSE23400 | MYH6 | 4624 | 214468_at | -0.0424 | 0.0169 | |
| GSE26886 | MYH6 | 4624 | 214468_at | -0.1545 | 0.2602 | |
| GSE29001 | MYH6 | 4624 | 214468_at | 0.0059 | 0.9686 | |
| GSE38129 | MYH6 | 4624 | 214468_at | -0.1319 | 0.0081 | |
| GSE45670 | MYH6 | 4624 | 214468_at | 0.0722 | 0.3427 | |
| GSE53622 | MYH6 | 4624 | 137427 | 0.3224 | 0.0212 | |
| GSE53624 | MYH6 | 4624 | 137427 | 0.1504 | 0.1848 | |
| GSE63941 | MYH6 | 4624 | 214468_at | 0.2581 | 0.0415 | |
| GSE77861 | MYH6 | 4624 | 214468_at | -0.1866 | 0.1144 | |
| GSE97050 | MYH6 | A_21_P0013396 | -2.9392 | 0.0545 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYH6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH6 | 4624 | 9 | 1 | 20 | |
| GSE20123 | MYH6 | 4624 | 8 | 1 | 21 | |
| GSE43470 | MYH6 | 4624 | 7 | 2 | 34 | |
| GSE46452 | MYH6 | 4624 | 17 | 2 | 40 | |
| GSE47630 | MYH6 | 4624 | 11 | 10 | 19 | |
| GSE54993 | MYH6 | 4624 | 3 | 11 | 56 | |
| GSE54994 | MYH6 | 4624 | 18 | 5 | 30 | |
| GSE60625 | MYH6 | 4624 | 0 | 2 | 9 | |
| GSE74703 | MYH6 | 4624 | 6 | 2 | 28 | |
| GSE74704 | MYH6 | 4624 | 3 | 1 | 16 | |
| TCGA | MYH6 | 4624 | 27 | 14 | 55 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of MYH6:
Generating mutation plots.
Highly correlated genes for MYH6:
Showing top 20/77 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH6 | FAM184B | 0.692164 | 3 | 0 | 3 |
| MYH6 | ANKRD30A | 0.661605 | 3 | 0 | 3 |
| MYH6 | OR1J4 | 0.642568 | 3 | 0 | 3 |
| MYH6 | KIAA0232 | 0.629399 | 3 | 0 | 3 |
| MYH6 | CRB3 | 0.628396 | 3 | 0 | 3 |
| MYH6 | DRICH1 | 0.61498 | 4 | 0 | 4 |
| MYH6 | CST8 | 0.602084 | 3 | 0 | 3 |
| MYH6 | SLC22A31 | 0.58961 | 5 | 0 | 3 |
| MYH6 | LINC01213 | 0.588419 | 4 | 0 | 3 |
| MYH6 | ANKZF1 | 0.585448 | 3 | 0 | 3 |
| MYH6 | LINC01271 | 0.582826 | 3 | 0 | 3 |
| MYH6 | TSSK1B | 0.577888 | 4 | 0 | 3 |
| MYH6 | PFN4 | 0.576868 | 3 | 0 | 3 |
| MYH6 | CAMK1G | 0.574113 | 4 | 0 | 4 |
| MYH6 | TAS2R41 | 0.572431 | 3 | 0 | 3 |
| MYH6 | RPGRIP1 | 0.567829 | 3 | 0 | 3 |
| MYH6 | WDR31 | 0.565043 | 4 | 0 | 4 |
| MYH6 | ATP8A1 | 0.559806 | 3 | 0 | 3 |
| MYH6 | HMHB1 | 0.559104 | 4 | 0 | 3 |
| MYH6 | IL17RC | 0.556536 | 5 | 0 | 3 |
For details and further investigation, click here
