| Full name: crumbs cell polarity complex component 3 | Alias Symbol: MGC17303 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 92359 | HGNC ID: HGNC:20237 | Ensembl Gene: ENSG00000130545 | OMIM ID: 609737 |
| Drug and gene relationship at DGIdb | |||
Expression of CRB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRB3 | 92359 | 232609_at | -0.4975 | 0.1657 | |
| GSE26886 | CRB3 | 92359 | 232609_at | -0.4490 | 0.0034 | |
| GSE45670 | CRB3 | 92359 | 232609_at | 0.0126 | 0.9555 | |
| GSE53622 | CRB3 | 92359 | 42891 | -0.8748 | 0.0000 | |
| GSE53624 | CRB3 | 92359 | 42891 | -1.0829 | 0.0000 | |
| GSE63941 | CRB3 | 92359 | 232609_at | 1.7554 | 0.0008 | |
| GSE77861 | CRB3 | 92359 | 232609_at | -0.4563 | 0.0203 | |
| GSE97050 | CRB3 | 92359 | A_33_P3256391 | 0.1189 | 0.7674 | |
| SRP007169 | CRB3 | 92359 | RNAseq | -1.9803 | 0.0000 | |
| SRP008496 | CRB3 | 92359 | RNAseq | -2.0898 | 0.0000 | |
| SRP064894 | CRB3 | 92359 | RNAseq | -1.4818 | 0.0005 | |
| SRP133303 | CRB3 | 92359 | RNAseq | -0.8391 | 0.0040 | |
| SRP159526 | CRB3 | 92359 | RNAseq | -1.0331 | 0.0436 | |
| SRP193095 | CRB3 | 92359 | RNAseq | -1.2966 | 0.0000 | |
| SRP219564 | CRB3 | 92359 | RNAseq | -1.2744 | 0.1121 | |
| TCGA | CRB3 | 92359 | RNAseq | -0.1473 | 0.3382 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by CRB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRB3 | 92359 | 5 | 3 | 22 | |
| GSE20123 | CRB3 | 92359 | 4 | 2 | 24 | |
| GSE43470 | CRB3 | 92359 | 2 | 6 | 35 | |
| GSE46452 | CRB3 | 92359 | 47 | 1 | 11 | |
| GSE47630 | CRB3 | 92359 | 5 | 7 | 28 | |
| GSE54993 | CRB3 | 92359 | 16 | 3 | 51 | |
| GSE54994 | CRB3 | 92359 | 6 | 14 | 33 | |
| GSE60625 | CRB3 | 92359 | 9 | 0 | 2 | |
| GSE74703 | CRB3 | 92359 | 2 | 4 | 30 | |
| GSE74704 | CRB3 | 92359 | 1 | 2 | 17 | |
| TCGA | CRB3 | 92359 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of CRB3:
Generating mutation plots.
Highly correlated genes for CRB3:
Showing top 20/1082 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRB3 | DNAH6 | 0.773458 | 3 | 0 | 3 |
| CRB3 | SH3GL1 | 0.751123 | 6 | 0 | 6 |
| CRB3 | RASAL1 | 0.727829 | 7 | 0 | 6 |
| CRB3 | TMEM141 | 0.727624 | 4 | 0 | 3 |
| CRB3 | SDCBP2 | 0.726463 | 4 | 0 | 4 |
| CRB3 | SCNN1B | 0.722534 | 8 | 0 | 7 |
| CRB3 | AMBRA1 | 0.721991 | 3 | 0 | 3 |
| CRB3 | CEACAM1 | 0.720965 | 7 | 0 | 7 |
| CRB3 | GRHL1 | 0.719915 | 9 | 0 | 8 |
| CRB3 | PRSS8 | 0.719832 | 6 | 0 | 6 |
| CRB3 | ATG9B | 0.719194 | 7 | 0 | 7 |
| CRB3 | EPHA1 | 0.719115 | 9 | 0 | 8 |
| CRB3 | CAMSAP3 | 0.717035 | 8 | 0 | 8 |
| CRB3 | EPN3 | 0.716725 | 8 | 0 | 7 |
| CRB3 | DENND2D | 0.716412 | 6 | 0 | 6 |
| CRB3 | TMEM40 | 0.715495 | 9 | 0 | 8 |
| CRB3 | GRHL3 | 0.715005 | 9 | 0 | 8 |
| CRB3 | CLVS1 | 0.714084 | 3 | 0 | 3 |
| CRB3 | LIPH | 0.713179 | 8 | 0 | 8 |
| CRB3 | MPZL3 | 0.711101 | 8 | 0 | 7 |
For details and further investigation, click here
