| Full name: profilin family member 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 375189 | HGNC ID: HGNC:31103 | Ensembl Gene: ENSG00000176732 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
PFN4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05132 | Salmonella infection |
Expression of PFN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PFN4 | 375189 | 1557476_at | 0.2554 | 0.2039 | |
| GSE26886 | PFN4 | 375189 | 235627_at | -0.4611 | 0.0046 | |
| GSE45670 | PFN4 | 375189 | 235627_at | -0.1565 | 0.1850 | |
| GSE53622 | PFN4 | 375189 | 8907 | 0.0996 | 0.3524 | |
| GSE53624 | PFN4 | 375189 | 8907 | -0.1076 | 0.2913 | |
| GSE63941 | PFN4 | 375189 | 1557476_at | 0.3402 | 0.0363 | |
| GSE77861 | PFN4 | 375189 | 235627_at | -0.1520 | 0.0690 | |
| GSE97050 | PFN4 | 375189 | A_23_P16798 | 0.0217 | 0.9385 | |
| SRP133303 | PFN4 | 375189 | RNAseq | -0.8283 | 0.0045 | |
| SRP219564 | PFN4 | 375189 | RNAseq | -0.1240 | 0.8108 | |
| TCGA | PFN4 | 375189 | RNAseq | 0.4021 | 0.3555 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PFN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PFN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PFN4 | 375189 | 10 | 2 | 18 | |
| GSE20123 | PFN4 | 375189 | 10 | 2 | 18 | |
| GSE43470 | PFN4 | 375189 | 2 | 1 | 40 | |
| GSE46452 | PFN4 | 375189 | 3 | 4 | 52 | |
| GSE47630 | PFN4 | 375189 | 8 | 0 | 32 | |
| GSE54993 | PFN4 | 375189 | 0 | 7 | 63 | |
| GSE54994 | PFN4 | 375189 | 10 | 0 | 43 | |
| GSE60625 | PFN4 | 375189 | 0 | 3 | 8 | |
| GSE74703 | PFN4 | 375189 | 2 | 0 | 34 | |
| GSE74704 | PFN4 | 375189 | 9 | 1 | 10 | |
| TCGA | PFN4 | 375189 | 36 | 4 | 56 |
Total number of gains: 90; Total number of losses: 24; Total Number of normals: 374.
Somatic mutations of PFN4:
Generating mutation plots.
Highly correlated genes for PFN4:
Showing top 20/78 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PFN4 | CLCNKB | 0.765105 | 3 | 0 | 3 |
| PFN4 | ZNF341 | 0.733514 | 3 | 0 | 3 |
| PFN4 | CNTD2 | 0.724076 | 3 | 0 | 3 |
| PFN4 | GABRD | 0.707099 | 3 | 0 | 3 |
| PFN4 | PDYN | 0.677952 | 3 | 0 | 3 |
| PFN4 | ACTR8 | 0.65849 | 3 | 0 | 3 |
| PFN4 | CDK16 | 0.658244 | 3 | 0 | 3 |
| PFN4 | CACNA1G | 0.655136 | 4 | 0 | 3 |
| PFN4 | HMBS | 0.652311 | 3 | 0 | 3 |
| PFN4 | IL10RA | 0.64734 | 3 | 0 | 3 |
| PFN4 | BTK | 0.645105 | 3 | 0 | 3 |
| PFN4 | CELF4 | 0.642748 | 3 | 0 | 3 |
| PFN4 | GPHA2 | 0.638739 | 3 | 0 | 3 |
| PFN4 | DDC | 0.634307 | 4 | 0 | 3 |
| PFN4 | RENBP | 0.630715 | 4 | 0 | 3 |
| PFN4 | KCNT1 | 0.626712 | 3 | 0 | 3 |
| PFN4 | SMC1B | 0.626367 | 3 | 0 | 3 |
| PFN4 | ESAM | 0.626306 | 3 | 0 | 3 |
| PFN4 | SDR42E1 | 0.62407 | 3 | 0 | 3 |
| PFN4 | ZFYVE19 | 0.61991 | 3 | 0 | 3 |
For details and further investigation, click here
