NEFM

 

Full name: neurofilament medium Alias Symbol: NFM|NF-M
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 4741 HGNC ID: HGNC:7734 Ensembl Gene: ENSG00000104722 OMIM ID: 162250
Drug and gene relationship at DGIdb

 

NEFM involved pathways:

KEGG pathway Description View
hsa05014Amyotrophic lateral sclerosis (ALS)

 

Expression of NEFM:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NEFM 4741 205113_at 0.4120 0.8001
GSE20347 NEFM 4741 205113_at 0.4992 0.2610
GSE23400 NEFM 4741 205113_at -0.0529 0.7107
GSE26886 NEFM 4741 205113_at -0.3372 0.7987
GSE29001 NEFM 4741 205113_at 0.3069 0.7641
GSE38129 NEFM 4741 205113_at 0.3901 0.3448
GSE45670 NEFM 4741 205113_at 0.9182 0.4005
GSE53622 NEFM 4741 100583 -0.5987 0.0642
GSE53624 NEFM 4741 100583 -0.7265 0.0036
GSE63941 NEFM 4741 205113_at -0.5217 0.6195
GSE77861 NEFM 4741 205113_at 0.3841 0.7509
SRP064894 NEFM 4741 RNAseq -1.4025 0.0049
SRP133303 NEFM 4741 RNAseq -2.0916 0.0002
SRP159526 NEFM 4741 RNAseq -0.6206 0.4178
TCGA NEFM 4741 RNAseq 0.4662 0.3675

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by NEFM expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NEFM:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NEFM 4741 4 12 14
GSE20123 NEFM 4741 4 12 14
GSE43470 NEFM 4741 4 7 32
GSE46452 NEFM 4741 13 13 33
GSE47630 NEFM 4741 10 8 22
GSE54993 NEFM 4741 2 14 54
GSE54994 NEFM 4741 8 18 27
GSE60625 NEFM 4741 3 0 8
GSE74703 NEFM 4741 4 6 26
GSE74704 NEFM 4741 3 8 9
TCGA NEFM 4741 15 43 38

Total number of gains: 70; Total number of losses: 141; Total Number of normals: 277.  

 

Somatic mutations of NEFM:

 

Generating mutation plots.

 

Highly correlated genes for NEFM:

 

Showing all 9 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NEFMABCB60.660737303
NEFMBLMH0.586141404
NEFMANXA100.577061504
NEFMITGA40.564162303
NEFMNQO10.552827303
NEFMNEFL0.5486391207
NEFMTWIST20.527338303
NEFMHEG10.514852403
NEFMGCLM0.50628704

For details and further investigation, click here