| Full name: glutamate-cysteine ligase modifier subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p22.1 | ||
| Entrez ID: 2730 | HGNC ID: HGNC:4312 | Ensembl Gene: ENSG00000023909 | OMIM ID: 601176 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GCLM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCLM | 2730 | 203925_at | 0.6713 | 0.5845 | |
| GSE20347 | GCLM | 2730 | 203925_at | 1.7080 | 0.0000 | |
| GSE23400 | GCLM | 2730 | 203925_at | 1.4743 | 0.0000 | |
| GSE26886 | GCLM | 2730 | 203925_at | 0.2000 | 0.6417 | |
| GSE29001 | GCLM | 2730 | 203925_at | 0.6500 | 0.2219 | |
| GSE38129 | GCLM | 2730 | 203925_at | 1.9024 | 0.0000 | |
| GSE45670 | GCLM | 2730 | 203925_at | 1.1928 | 0.0082 | |
| GSE53622 | GCLM | 2730 | 106725 | 0.2930 | 0.0033 | |
| GSE53624 | GCLM | 2730 | 106725 | 0.2822 | 0.0011 | |
| GSE63941 | GCLM | 2730 | 203925_at | -1.2979 | 0.1171 | |
| GSE77861 | GCLM | 2730 | 203925_at | 1.0162 | 0.1118 | |
| GSE97050 | GCLM | 2730 | A_33_P3265606 | -0.1504 | 0.4848 | |
| SRP007169 | GCLM | 2730 | RNAseq | 1.1705 | 0.0851 | |
| SRP008496 | GCLM | 2730 | RNAseq | 1.4604 | 0.0213 | |
| SRP064894 | GCLM | 2730 | RNAseq | 0.4637 | 0.1614 | |
| SRP133303 | GCLM | 2730 | RNAseq | 1.7392 | 0.0000 | |
| SRP193095 | GCLM | 2730 | RNAseq | 1.6856 | 0.0000 | |
| SRP219564 | GCLM | 2730 | RNAseq | 0.1246 | 0.8336 | |
| TCGA | GCLM | 2730 | RNAseq | 0.4549 | 0.0017 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by GCLM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCLM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCLM | 2730 | 0 | 8 | 22 | |
| GSE20123 | GCLM | 2730 | 0 | 8 | 22 | |
| GSE43470 | GCLM | 2730 | 2 | 6 | 35 | |
| GSE46452 | GCLM | 2730 | 1 | 1 | 57 | |
| GSE47630 | GCLM | 2730 | 8 | 5 | 27 | |
| GSE54993 | GCLM | 2730 | 0 | 1 | 69 | |
| GSE54994 | GCLM | 2730 | 6 | 3 | 44 | |
| GSE60625 | GCLM | 2730 | 0 | 0 | 11 | |
| GSE74703 | GCLM | 2730 | 1 | 5 | 30 | |
| GSE74704 | GCLM | 2730 | 0 | 5 | 15 | |
| TCGA | GCLM | 2730 | 6 | 24 | 66 |
Total number of gains: 24; Total number of losses: 66; Total Number of normals: 398.
Somatic mutations of GCLM:
Generating mutation plots.
Highly correlated genes for GCLM:
Showing top 20/247 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCLM | MRGPRG | 0.802658 | 3 | 0 | 3 |
| GCLM | RBM43 | 0.787855 | 4 | 0 | 4 |
| GCLM | YY2 | 0.783609 | 3 | 0 | 3 |
| GCLM | C19orf73 | 0.777686 | 3 | 0 | 3 |
| GCLM | MRPS16 | 0.777369 | 3 | 0 | 3 |
| GCLM | PRSS38 | 0.757502 | 3 | 0 | 3 |
| GCLM | C1QL2 | 0.752528 | 3 | 0 | 3 |
| GCLM | PALM3 | 0.750727 | 3 | 0 | 3 |
| GCLM | CDCA5 | 0.737855 | 3 | 0 | 3 |
| GCLM | DCDC1 | 0.737174 | 3 | 0 | 3 |
| GCLM | C20orf85 | 0.733482 | 3 | 0 | 3 |
| GCLM | BBC3 | 0.731174 | 3 | 0 | 3 |
| GCLM | OR1J1 | 0.730442 | 3 | 0 | 3 |
| GCLM | C10orf91 | 0.725565 | 3 | 0 | 3 |
| GCLM | PRKAG3 | 0.724461 | 3 | 0 | 3 |
| GCLM | C9orf153 | 0.72389 | 3 | 0 | 3 |
| GCLM | OR2B11 | 0.721365 | 3 | 0 | 3 |
| GCLM | LBX2 | 0.720091 | 3 | 0 | 3 |
| GCLM | TNFAIP8L1 | 0.718932 | 5 | 0 | 5 |
| GCLM | FAM71F1 | 0.718003 | 4 | 0 | 4 |
For details and further investigation, click here
