| Full name: twist family bHLH transcription factor 2 | Alias Symbol: DERMO1|Dermo-1|bHLHa39 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 117581 | HGNC ID: HGNC:20670 | Ensembl Gene: ENSG00000233608 | OMIM ID: 607556 |
| Drug and gene relationship at DGIdb | |||
TWIST2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of TWIST2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TWIST2 | 117581 | 229404_at | 0.4688 | 0.7099 | |
| GSE26886 | TWIST2 | 117581 | 229404_at | 1.1529 | 0.0005 | |
| GSE45670 | TWIST2 | 117581 | 229404_at | -0.2740 | 0.5783 | |
| GSE53622 | TWIST2 | 117581 | 99775 | -0.1907 | 0.0925 | |
| GSE53624 | TWIST2 | 117581 | 99775 | 0.3572 | 0.0009 | |
| GSE63941 | TWIST2 | 117581 | 229404_at | -2.3507 | 0.0349 | |
| GSE77861 | TWIST2 | 117581 | 229404_at | 0.6038 | 0.0495 | |
| GSE97050 | TWIST2 | A_19_P00322911 | -0.1117 | 0.7306 | ||
| SRP064894 | TWIST2 | 117581 | RNAseq | 0.1601 | 0.6717 | |
| SRP133303 | TWIST2 | 117581 | RNAseq | -0.1772 | 0.6554 | |
| SRP159526 | TWIST2 | 117581 | RNAseq | 1.6565 | 0.0089 | |
| SRP219564 | TWIST2 | 117581 | RNAseq | 1.0677 | 0.0853 | |
| TCGA | TWIST2 | 117581 | RNAseq | 0.3130 | 0.1449 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by TWIST2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TWIST2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TWIST2 | 117581 | 1 | 12 | 17 | |
| GSE20123 | TWIST2 | 117581 | 1 | 12 | 17 | |
| GSE43470 | TWIST2 | 117581 | 1 | 9 | 33 | |
| GSE46452 | TWIST2 | 117581 | 0 | 5 | 54 | |
| GSE47630 | TWIST2 | 117581 | 4 | 5 | 31 | |
| GSE54993 | TWIST2 | 117581 | 3 | 3 | 64 | |
| GSE54994 | TWIST2 | 117581 | 8 | 9 | 36 | |
| GSE60625 | TWIST2 | 117581 | 0 | 3 | 8 | |
| GSE74703 | TWIST2 | 117581 | 1 | 7 | 28 | |
| GSE74704 | TWIST2 | 117581 | 1 | 5 | 14 | |
| TCGA | TWIST2 | 117581 | 12 | 28 | 56 |
Total number of gains: 32; Total number of losses: 98; Total Number of normals: 358.
Somatic mutations of TWIST2:
Generating mutation plots.
Highly correlated genes for TWIST2:
Showing top 20/300 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TWIST2 | INVS | 0.785745 | 3 | 0 | 3 |
| TWIST2 | MSN | 0.766971 | 3 | 0 | 3 |
| TWIST2 | POU6F2-AS2 | 0.750844 | 3 | 0 | 3 |
| TWIST2 | HOXD10 | 0.71926 | 3 | 0 | 3 |
| TWIST2 | SPIRE1 | 0.716561 | 3 | 0 | 3 |
| TWIST2 | WIPF1 | 0.700404 | 3 | 0 | 3 |
| TWIST2 | TEAD4 | 0.688046 | 3 | 0 | 3 |
| TWIST2 | LAMC2 | 0.683001 | 3 | 0 | 3 |
| TWIST2 | FLRT3 | 0.682344 | 4 | 0 | 3 |
| TWIST2 | SERPINA3 | 0.678676 | 3 | 0 | 3 |
| TWIST2 | ASH1L-AS1 | 0.678018 | 3 | 0 | 3 |
| TWIST2 | TENM2 | 0.672138 | 4 | 0 | 3 |
| TWIST2 | FBN1 | 0.666709 | 4 | 0 | 4 |
| TWIST2 | ANXA5 | 0.665703 | 5 | 0 | 4 |
| TWIST2 | STMN3 | 0.662359 | 4 | 0 | 4 |
| TWIST2 | MCAM | 0.661669 | 4 | 0 | 4 |
| TWIST2 | RFTN1 | 0.661495 | 4 | 0 | 3 |
| TWIST2 | ITPK1 | 0.660305 | 3 | 0 | 3 |
| TWIST2 | SLC47A2 | 0.657848 | 3 | 0 | 3 |
| TWIST2 | PHF19 | 0.657679 | 3 | 0 | 3 |
For details and further investigation, click here
