| Full name: neurofilament light | Alias Symbol: NFL|CMT1F|CMT2E|NF68|PPP1R110 | ||
| Type: protein-coding gene | Cytoband: 8p21.2 | ||
| Entrez ID: 4747 | HGNC ID: HGNC:7739 | Ensembl Gene: ENSG00000277586 | OMIM ID: 162280 |
| Drug and gene relationship at DGIdb | |||
NEFL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of NEFL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEFL | 4747 | 221805_at | 0.7937 | 0.8325 | |
| GSE20347 | NEFL | 4747 | 221916_at | 1.2145 | 0.1048 | |
| GSE23400 | NEFL | 4747 | 221805_at | 1.4291 | 0.0000 | |
| GSE26886 | NEFL | 4747 | 221916_at | 1.2342 | 0.2559 | |
| GSE29001 | NEFL | 4747 | 221916_at | 0.7285 | 0.3906 | |
| GSE38129 | NEFL | 4747 | 221916_at | 0.7649 | 0.1964 | |
| GSE45670 | NEFL | 4747 | 221805_at | 2.3709 | 0.0107 | |
| GSE53622 | NEFL | 4747 | 46194 | 0.2102 | 0.5884 | |
| GSE53624 | NEFL | 4747 | 46194 | 0.7018 | 0.0070 | |
| GSE63941 | NEFL | 4747 | 221916_at | 1.1146 | 0.5389 | |
| GSE77861 | NEFL | 4747 | 221916_at | 0.8182 | 0.4164 | |
| GSE97050 | NEFL | 4747 | A_33_P3287785 | -0.1461 | 0.8138 | |
| SRP064894 | NEFL | 4747 | RNAseq | 1.3897 | 0.0234 | |
| SRP133303 | NEFL | 4747 | RNAseq | 0.4974 | 0.6251 | |
| SRP159526 | NEFL | 4747 | RNAseq | 1.1321 | 0.2491 | |
| SRP219564 | NEFL | 4747 | RNAseq | 2.4952 | 0.0320 | |
| TCGA | NEFL | 4747 | RNAseq | 0.9399 | 0.0134 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by NEFL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEFL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEFL | 4747 | 4 | 12 | 14 | |
| GSE20123 | NEFL | 4747 | 4 | 12 | 14 | |
| GSE43470 | NEFL | 4747 | 4 | 7 | 32 | |
| GSE46452 | NEFL | 4747 | 13 | 13 | 33 | |
| GSE47630 | NEFL | 4747 | 10 | 8 | 22 | |
| GSE54993 | NEFL | 4747 | 2 | 14 | 54 | |
| GSE54994 | NEFL | 4747 | 8 | 18 | 27 | |
| GSE60625 | NEFL | 4747 | 3 | 0 | 8 | |
| GSE74703 | NEFL | 4747 | 4 | 6 | 26 | |
| GSE74704 | NEFL | 4747 | 3 | 8 | 9 | |
| TCGA | NEFL | 4747 | 15 | 43 | 38 |
Total number of gains: 70; Total number of losses: 141; Total Number of normals: 277.
Somatic mutations of NEFL:
Generating mutation plots.
Highly correlated genes for NEFL:
Showing top 20/117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEFL | HSPA13 | 0.693706 | 3 | 0 | 3 |
| NEFL | BLACAT1 | 0.691899 | 3 | 0 | 3 |
| NEFL | FAM169A | 0.657624 | 6 | 0 | 5 |
| NEFL | AKR1C2 | 0.638591 | 4 | 0 | 4 |
| NEFL | CNTNAP2 | 0.631127 | 4 | 0 | 4 |
| NEFL | TMEM17 | 0.628605 | 4 | 0 | 4 |
| NEFL | MB21D2 | 0.627664 | 4 | 0 | 3 |
| NEFL | POPDC3 | 0.618785 | 7 | 0 | 5 |
| NEFL | GALNT18 | 0.613279 | 4 | 0 | 3 |
| NEFL | MYO1D | 0.608186 | 3 | 0 | 3 |
| NEFL | BAMBI | 0.607029 | 3 | 0 | 3 |
| NEFL | RBP1 | 0.605032 | 6 | 0 | 4 |
| NEFL | PNO1 | 0.602797 | 3 | 0 | 3 |
| NEFL | SKA3 | 0.599377 | 3 | 0 | 3 |
| NEFL | AMIGO2 | 0.597201 | 7 | 0 | 4 |
| NEFL | MMP14 | 0.594201 | 3 | 0 | 3 |
| NEFL | SSR3 | 0.591696 | 3 | 0 | 3 |
| NEFL | AFAP1L2 | 0.591191 | 4 | 0 | 3 |
| NEFL | EFNB2 | 0.587364 | 7 | 0 | 5 |
| NEFL | WDR54 | 0.58648 | 4 | 0 | 3 |
For details and further investigation, click here
