NQO1

 

Full name: NAD(P)H quinone dehydrogenase 1 Alias Symbol: DHQU|QR1|DTD
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 1728 HGNC ID: HGNC:2874 Ensembl Gene: ENSG00000181019 OMIM ID: 125860
Drug and gene relationship at DGIdb

 

Expression of NQO1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NQO1 1728 210519_s_at -0.1404 0.9164
GSE20347 NQO1 1728 201468_s_at -0.6074 0.2191
GSE23400 NQO1 1728 210519_s_at -0.0455 0.8399
GSE26886 NQO1 1728 201468_s_at -0.3306 0.6251
GSE29001 NQO1 1728 201468_s_at -1.0864 0.0541
GSE38129 NQO1 1728 201468_s_at -0.3400 0.4320
GSE45670 NQO1 1728 210519_s_at -0.2771 0.5630
GSE63941 NQO1 1728 210519_s_at -0.4453 0.5800
GSE77861 NQO1 1728 201468_s_at 0.2552 0.6642
GSE97050 NQO1 1728 A_23_P206661 -0.6756 0.1465
SRP007169 NQO1 1728 RNAseq -0.6109 0.2506
SRP008496 NQO1 1728 RNAseq -0.1464 0.7708
SRP064894 NQO1 1728 RNAseq -1.1574 0.0004
SRP133303 NQO1 1728 RNAseq -0.4570 0.0896
SRP159526 NQO1 1728 RNAseq 1.2289 0.1074
SRP193095 NQO1 1728 RNAseq -0.6093 0.0738
SRP219564 NQO1 1728 RNAseq -0.2576 0.7993
TCGA NQO1 1728 RNAseq -0.2066 0.1243

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by NQO1 expression:

 

TCGA

 

Note: Click image to view full size file.  


Copy number change of NQO1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NQO1 1728 8 1 21
GSE20123 NQO1 1728 8 1 21
GSE43470 NQO1 1728 2 8 33
GSE46452 NQO1 1728 38 1 20
GSE47630 NQO1 1728 11 8 21
GSE54993 NQO1 1728 2 4 64
GSE54994 NQO1 1728 8 10 35
GSE60625 NQO1 1728 4 0 7
GSE74703 NQO1 1728 2 5 29
GSE74704 NQO1 1728 4 0 16
TCGA NQO1 1728 28 12 56

Total number of gains: 115; Total number of losses: 50; Total Number of normals: 323.  


 

Somatic mutations of NQO1:

 

Generating mutation plots.

 

Highly correlated genes for NQO1:

 

Showing top 20/101 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NQO1WDFY20.68983303
NQO1SRXN10.687238707
NQO1AKR1C30.68450411011
NQO1AKR1C20.68028810010
NQO1TALDO10.67395711010
NQO1TKT0.673941908
NQO1AKR1C10.6677071009
NQO1CYP4F30.6667721009
NQO1G6PD0.666024908
NQO1ALDH3A10.65634411010
NQO1ABCC30.6543391009
NQO1TSPAN70.6505391007
NQO1NDUFA60.643513404
NQO1AKR1B100.6434121109
NQO1NHSL10.628609303
NQO1ME10.6254591109
NQO1MRPL400.620331303
NQO1SESN30.615798303
NQO1CYP4F20.6099081109
NQO1CYP4F110.6060661007

For details and further investigation, click here