| Full name: heart development protein with EGF like domains 1 | Alias Symbol: KIAA1237|HEG | ||
| Type: protein-coding gene | Cytoband: 3q21.2 | ||
| Entrez ID: 57493 | HGNC ID: HGNC:29227 | Ensembl Gene: ENSG00000173706 | OMIM ID: 614182 |
| Drug and gene relationship at DGIdb | |||
Expression of HEG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HEG1 | 57493 | 213069_at | 0.0291 | 0.9661 | |
| GSE20347 | HEG1 | 57493 | 213069_at | 0.4002 | 0.1088 | |
| GSE23400 | HEG1 | 57493 | 212822_at | 0.0772 | 0.2379 | |
| GSE26886 | HEG1 | 57493 | 213069_at | -0.0324 | 0.9366 | |
| GSE29001 | HEG1 | 57493 | 213069_at | 0.3758 | 0.4300 | |
| GSE38129 | HEG1 | 57493 | 213069_at | 0.2206 | 0.3150 | |
| GSE45670 | HEG1 | 57493 | 213069_at | -0.2926 | 0.3265 | |
| GSE53622 | HEG1 | 57493 | 113042 | 0.1053 | 0.2817 | |
| GSE53624 | HEG1 | 57493 | 113042 | 0.1793 | 0.0610 | |
| GSE63941 | HEG1 | 57493 | 213069_at | -4.7994 | 0.0033 | |
| GSE77861 | HEG1 | 57493 | 213069_at | -0.0932 | 0.8975 | |
| GSE97050 | HEG1 | 57493 | A_32_P166693 | -0.2107 | 0.5824 | |
| SRP007169 | HEG1 | 57493 | RNAseq | 1.5464 | 0.0009 | |
| SRP008496 | HEG1 | 57493 | RNAseq | 1.5561 | 0.0000 | |
| SRP064894 | HEG1 | 57493 | RNAseq | 0.2934 | 0.2893 | |
| SRP133303 | HEG1 | 57493 | RNAseq | 0.3653 | 0.1490 | |
| SRP159526 | HEG1 | 57493 | RNAseq | 0.5017 | 0.1907 | |
| SRP193095 | HEG1 | 57493 | RNAseq | 0.7738 | 0.0000 | |
| SRP219564 | HEG1 | 57493 | RNAseq | -0.0239 | 0.9594 | |
| TCGA | HEG1 | 57493 | RNAseq | -0.0104 | 0.9088 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by HEG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HEG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HEG1 | 57493 | 17 | 0 | 13 | |
| GSE20123 | HEG1 | 57493 | 17 | 0 | 13 | |
| GSE43470 | HEG1 | 57493 | 20 | 0 | 23 | |
| GSE46452 | HEG1 | 57493 | 14 | 5 | 40 | |
| GSE47630 | HEG1 | 57493 | 17 | 4 | 19 | |
| GSE54993 | HEG1 | 57493 | 2 | 7 | 61 | |
| GSE54994 | HEG1 | 57493 | 31 | 3 | 19 | |
| GSE60625 | HEG1 | 57493 | 0 | 6 | 5 | |
| GSE74703 | HEG1 | 57493 | 17 | 0 | 19 | |
| GSE74704 | HEG1 | 57493 | 13 | 0 | 7 | |
| TCGA | HEG1 | 57493 | 56 | 6 | 34 |
Total number of gains: 204; Total number of losses: 31; Total Number of normals: 253.
Somatic mutations of HEG1:
Generating mutation plots.
Highly correlated genes for HEG1:
Showing top 20/405 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HEG1 | GLIPR2 | 0.728608 | 3 | 0 | 3 |
| HEG1 | REEP2 | 0.700936 | 3 | 0 | 3 |
| HEG1 | TCP11L1 | 0.677521 | 3 | 0 | 3 |
| HEG1 | GOLGA3 | 0.661105 | 3 | 0 | 3 |
| HEG1 | FBN1 | 0.660548 | 8 | 0 | 6 |
| HEG1 | TLN2 | 0.658195 | 3 | 0 | 3 |
| HEG1 | PTX3 | 0.657932 | 3 | 0 | 3 |
| HEG1 | SLIT3 | 0.652878 | 4 | 0 | 3 |
| HEG1 | SH3RF3 | 0.652514 | 4 | 0 | 3 |
| HEG1 | HBD | 0.644133 | 3 | 0 | 3 |
| HEG1 | TIMP3 | 0.640617 | 8 | 0 | 6 |
| HEG1 | OPTN | 0.634023 | 3 | 0 | 3 |
| HEG1 | DNAJC18 | 0.632846 | 3 | 0 | 3 |
| HEG1 | UBE2G2 | 0.632801 | 3 | 0 | 3 |
| HEG1 | TCF7L1 | 0.630531 | 4 | 0 | 3 |
| HEG1 | DLC1 | 0.62961 | 7 | 0 | 5 |
| HEG1 | LIMS2 | 0.623497 | 5 | 0 | 4 |
| HEG1 | DNALI1 | 0.622009 | 3 | 0 | 3 |
| HEG1 | BCAP29 | 0.616837 | 3 | 0 | 3 |
| HEG1 | MAP4 | 0.616337 | 5 | 0 | 4 |
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