PLA2G4E

 

Full name: phospholipase A2 group IVE Alias Symbol: FLJ45651
Type: protein-coding gene Cytoband: 15q15.1
Entrez ID: 123745 HGNC ID: HGNC:24791 Ensembl Gene: ENSG00000188089 OMIM ID: 
Drug and gene relationship at DGIdb

 

PLA2G4E involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04611Platelet activation
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04724Glutamatergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04921Oxytocin signaling pathway
hsa05231Choline metabolism in cancer

 

Expression of PLA2G4E:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 PLA2G4E 123745 58902 1.1741 0.0026
GSE53624 PLA2G4E 123745 58902 0.9424 0.0001
SRP064894 PLA2G4E 123745 RNAseq 1.9086 0.0079
SRP133303 PLA2G4E 123745 RNAseq 1.5779 0.0233
SRP159526 PLA2G4E 123745 RNAseq 1.1386 0.2988
SRP219564 PLA2G4E 123745 RNAseq -0.8151 0.5194
TCGA PLA2G4E 123745 RNAseq 1.7042 0.0008

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by PLA2G4E expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLA2G4E:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLA2G4E 123745 4 5 21
GSE20123 PLA2G4E 123745 4 5 21
GSE43470 PLA2G4E 123745 4 5 34
GSE46452 PLA2G4E 123745 3 7 49
GSE47630 PLA2G4E 123745 8 11 21
GSE54993 PLA2G4E 123745 4 6 60
GSE54994 PLA2G4E 123745 5 7 41
GSE60625 PLA2G4E 123745 4 0 7
GSE74703 PLA2G4E 123745 4 4 28
GSE74704 PLA2G4E 123745 3 3 14
TCGA PLA2G4E 123745 11 17 68

Total number of gains: 54; Total number of losses: 70; Total Number of normals: 364.  

 

Somatic mutations of PLA2G4E:

 

Generating mutation plots.

 

Highly correlated genes for PLA2G4E:

 

Showing all 10 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLA2G4EALOXE30.72543303
PLA2G4EALOX12B0.702671303
PLA2G4EKRTDAP0.684722303
PLA2G4ES100A7A0.674337303
PLA2G4ESPRR2G0.671951303
PLA2G4EWFDC50.650115303
PLA2G4ES100A70.629015303
PLA2G4ECDSN0.623412303
PLA2G4ESLC28A30.602549303
PLA2G4ELYPD50.588625303

For details and further investigation, click here